Literature DB >> 21493144

Complex regulation and function of activation-induced cytidine deaminase.

Janet Stavnezer1.   

Abstract

Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation and class switch recombination during B cell activation in response to immunization and infection. This review discusses how AID expression and activity are regulated, including recent discoveries of AID-interacting proteins that might recruit AID to Ig genes, and allow it to target both DNA strands. Also discussed is the accumulating evidence that AID binds to, mutates, and creates breaks at numerous non-Ig sites in the genome, which initiates cell transformation and malignancies.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21493144      PMCID： PMC3090464          DOI： 10.1016/j.it.2011.03.003

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  92 in total

1.  Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.

Authors:  A Peters; U Storb
Journal:  Immunity       Date:  1996-01       Impact factor: 31.745

2.  Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination.

Authors:  Li Han; Shahnaz Masani; Kefei Yu
Journal:  J Immunol       Date:  2010-06-28       Impact factor: 5.422

3.  PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

Authors:  Laura Pasqualucci; Yasuyuki Kitaura; Hua Gu; Riccardo Dalla-Favera
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-30       Impact factor: 11.205

4.  Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.

Authors:  M Muramatsu; V S Sankaranand; S Anant; M Sugai; K Kinoshita; N O Davidson; T Honjo
Journal:  J Biol Chem       Date:  1999-06-25       Impact factor: 5.157

5.  Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.

Authors:  Hong Ming Shen; Ursula Storb
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-24       Impact factor: 11.205

6.  Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

Authors:  H M Shen; A Peters; B Baron; X Zhu; U Storb
Journal:  Science       Date:  1998-06-12       Impact factor: 47.728

7.  Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.

Authors:  Hugh D Morgan; Wendy Dean; Heather A Coker; Wolf Reik; Svend K Petersen-Mahrt
Journal:  J Biol Chem       Date:  2004-09-24       Impact factor: 5.157

8.  Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.

Authors:  Jayanta Chaudhuri; Chan Khuong; Frederick W Alt
Journal:  Nature       Date:  2004-07-25       Impact factor: 49.962

9.  BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.

Authors:  L Pasqualucci; A Migliazza; N Fracchiolla; C William; A Neri; L Baldini; R S Chaganti; U Klein; R Küppers; K Rajewsky; R Dalla-Favera
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-29       Impact factor: 11.205

10.  MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.

Authors:  Teresa M Wilson; Alexandra Vaisman; Stella A Martomo; Patsa Sullivan; Li Lan; Fumio Hanaoka; Akira Yasui; Roger Woodgate; Patricia J Gearhart
Journal:  J Exp Med       Date:  2005-02-14       Impact factor: 14.307
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  60 in total

1.  Designing redox potential-controlled protein switches based on mutually exclusive proteins.

Authors:  Qing Peng; Na Kong; Hui-Chuan Eileen Wang; Hongbin Li
Journal:  Protein Sci       Date:  2012-08       Impact factor: 6.725

Review 2.  Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.

Authors:  Zhenming Xu; Hong Zan; Egest J Pone; Thach Mai; Paolo Casali
Journal:  Nat Rev Immunol       Date:  2012-06-25       Impact factor: 53.106

Review 3.  Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.

Authors:  Bao Q Vuong; Jayanta Chaudhuri
Journal:  Semin Immunol       Date:  2012-07-06       Impact factor: 11.130

Review 4.  Functions and regulation of the APOBEC family of proteins.

Authors:  Harold C Smith; Ryan P Bennett; Ayse Kizilyer; William M McDougall; Kimberly M Prohaska
Journal:  Semin Cell Dev Biol       Date:  2011-10-06       Impact factor: 7.727

5.  Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination.

Authors:  Guideng Li; Zhenming Xu; Clayton A White; Tonika Lam; Egest J Pone; Daniel C Tran; Ken L Hayama; Hong Zan; Paolo Casali
Journal:  Cell Rep       Date:  2013-10-24       Impact factor: 9.423

Review 6.  T-bet-expressing B cells during HIV and HCV infections.

Authors:  James J Knox; David E Kaplan; Michael R Betts
Journal:  Cell Immunol       Date:  2017-07-11       Impact factor: 4.868

Review 7.  Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin.

Authors:  Wendy J Cannan; David S Pederson
Journal:  J Cell Physiol       Date:  2016-01       Impact factor: 6.384

8.  T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response.

Authors:  James J Knox; Marcus Buggert; Lela Kardava; Kelly E Seaton; Michael A Eller; David H Canaday; Merlin L Robb; Mario A Ostrowski; Steven G Deeks; Mark K Slifka; Georgia D Tomaras; Susan Moir; M Anthony Moody; Michael R Betts
Journal:  JCI Insight       Date:  2017-04-20

9.  AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.

Authors:  Xiwen Gu; Carmen J Booth; Zongzhi Liu; Matthew P Strout
Journal:  Blood       Date:  2015-09-18       Impact factor: 22.113

10.  Downregulation of FOXP1 is required during germinal center B-cell function.

Authors:  Ainara Sagardoy; Jose I Martinez-Ferrandis; Sergio Roa; Karen L Bunting; María Angela Aznar; Olivier Elemento; Rita Shaknovich; Lorena Fontán; Vicente Fresquet; Ignacio Perez-Roger; Eloy F Robles; Linde De Smedt; Xavier Sagaert; Ari Melnick; Jose A Martinez-Climent
Journal:  Blood       Date:  2013-04-11       Impact factor: 22.113
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