Investigation of optimal viewing size for detecting nodular ground-glass opacity on high-resolution computed tomography with cine-mode display.

We evaluated the effect of the displayed image sizes on observers' ability to detect nodular ground-glass opacity (n-GGO) on CT and investigated the optimal viewing size for soft-copy reading at CT screening for lung cancer. A total of 46 patients' high-resolution computed tomography (HRCT) images (22 patients with one GGO; 24 without GGO) were displayed on a monochromatic liquid crystal display monitor at a resolution of 1,200 × 1,600. HRCT was presented on the screen with cine-mode display. We compared two viewing sizes (original size, i.e., the image displayed with a zoom factor of 1 in which each pixel value in the image is displayed as one pixel on the display: 13 cm × 13 cm; fit size, i.e., by zooming the captured image until it occupies the entire screen: 30 cm × 30 cm) in terms of radiologists' performance for detecting n-GGO on HRCT and the viewing times required for soft-copy reading decisions. Observer performance was analyzed in terms of the receiver operating characteristic (ROC) curve. A statistically significant improvement was found with the original size in the average area-under-the-ROC curve values for the accuracy of diagnosis and the viewing times compared to the fit size (P < 0.05). The original size with cine-mode display leads to increased lung GGO detection at CT screening for lung cancer, and the reduced time spent performing the diagnosis offers cost savings.