Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

Literature DB >> 20740313

One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

D S Ermolat'ev¹, B Savaliya, A Shah, E Van der Eycken.

Abstract

An efficient microwave-assisted one-pot two-step protocol was developed for the construction of disubstituted 2-amino-1H-imidazoles. This process involves the sequential formation of 2,3-dihydro-2-hydroxyimidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and α-bromoketones, followed by cleavage of the pyrimidine ring with hydrazine.

Entities: Chemical

Mesh：

Substances：

Year: 2010 PMID： 20740313 DOI： 10.1007/s11030-010-9270-5

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

11 in total

1. Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).

Authors: D G Batt; J J Petraitis; G C Houghton; D P Modi; G A Cain; M H Corjay; S A Mousa; P J Bouchard; M S Forsythe; P P Harlow; F A Barbera; S M Spitz; R R Wexler; P K Jadhav
Journal: J Med Chem Date: 2000-01-13 Impact factor: 7.446

2. Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).

Authors: W J Pitts; J Wityak; J M Smallheer; A E Tobin; J W Jetter; J S Buynitsky; P P Harlow; K A Solomon; M H Corjay; S A Mousa; R R Wexler; P K Jadhav
Journal: J Med Chem Date: 2000-01-13 Impact factor: 7.446

3. A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines.

Authors: Denis S Ermolat'ev; Erik V Van der Eycken
Journal: J Org Chem Date: 2008-07-26 Impact factor: 4.354

4. Mode of action of the antitumor compound girodazole (RP 49532A, NSC 627434).

Authors: G Colson; B Rabault; F Lavelle; A Zerial
Journal: Biochem Pharmacol Date: 1992-04-15 Impact factor: 5.858

5. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.

Authors: J Kobayashi; Y Ohizumi; H Nakamura; Y Hirata
Journal: Experientia Date: 1986-10-15

6. Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.

Authors: Denis S Ermolat'ev; Eugene V Babaev; Erik V Van der Eycken
Journal: Org Lett Date: 2006-12-07 Impact factor: 6.005

7. Biogenetically inspired synthesis of marine C6N4 2-aminoimidazole alkaloids: Ab initio calculations, tautomerism, and reactivity.

Authors: Robert Abou-Jneid; Said Ghoulami; Marie-Thérèse Martin; Elise Tran Huu Dau; Nathalie Travert; Ali Al-Mourabit
Journal: Org Lett Date: 2004-10-28 Impact factor: 6.005

2. A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines.

Authors: Felicia Phei Lin Lim; Lin Yuing Tan; Edward R T Tiekink; Anton V Dolzhenko
Journal: RSC Adv Date: 2018-06-12 Impact factor: 3.361

2 in total

One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

1. Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).

2. Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).

3. A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines.

4. Mode of action of the antitumor compound girodazole (RP 49532A, NSC 627434).

5. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.

6. Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.

7. Biogenetically inspired synthesis of marine C6N4 2-aminoimidazole alkaloids: Ab initio calculations, tautomerism, and reactivity.

8. Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent.

9. New and biologically active imidazole alkaloids from two sponges of the genus Leucetta.

10. New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis.

1. A simple route for the synthesis of novel N-alkyl-2-(alkylthio)-1H-imidazole derivatives.

2. A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines.