Literature DB >> 15165143

New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis.

Wafaa Hassan1, RuAngelie Edrada, Rainer Ebel, Victor Wray, Albrecht Berg, Rob van Soest, Sumali Wiryowidagdo, Peter Proksch.   

Abstract

Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15165143     DOI： 10.1021/np0305223

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

1.  Total synthesis of 7'-desmethylkealiiquinone.

Authors:  Heather M Lima; Rasapalli Sivappa; Muhammed Yousufuddin; Carl J Lovely
Journal:  Org Lett       Date:  2012-04-24       Impact factor: 6.005

2.  A distinctive structural twist in the aminoimidazole alkaloids from a calcareous marine sponge: isolation and characterization of leucosolenamines A and B.

Authors:  Paul Ralifo; Karen Tenney; Frederick A Valeriote; Phillip Crews
Journal:  J Nat Prod       Date:  2007-01       Impact factor: 4.050

Review 3.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

4.  Total syntheses and cytotoxicity of kealiiquinone, 2-deoxy-2-aminokealiiquinone and analogs.

Authors:  Jayanta Das; Arunoday Bhan; Subhrangsu S Mandal; Carl J Lovely
Journal:  Bioorg Med Chem Lett       Date:  2013-09-06       Impact factor: 2.823

5.  Studies Towards the Leucetta-derived Alkaloids Spirocalcaridine A and B - Possible Biosynthetic Implications.

Authors:  Panduka B Koswatta; Jayanta Das; Muhammed Yousufuddin; Carl J Lovely
Journal:  European J Org Chem       Date:  2015-04

6.  Synthesis of the reported structures for kealiinines B and C.

Authors:  Joseph B Gibbons; Keith M Gligorich; Bryan E Welm; Ryan E Looper
Journal:  Org Lett       Date:  2012-09-11       Impact factor: 6.005

7.  Total syntheses of kealiinines A-C.

Authors:  Jayanta Das; Panduka B Koswatta; J Daniel Jones; Muhammed Yousufuddin; Carl J Lovely
Journal:  Org Lett       Date:  2012-12-05       Impact factor: 6.005

8.  One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

Authors:  D S Ermolat'ev; B Savaliya; A Shah; E Van der Eycken
Journal:  Mol Divers       Date:  2010-08-26       Impact factor: 2.943

9.  Two new imidazole alkaloids from Leucetta chagosensis sponge.

Authors:  Wafaa H B Hassan; Areej M Al-Taweel; Peter Proksch
Journal:  Saudi Pharm J       Date:  2009-11-10       Impact factor: 4.330

Review 10.  Imidazoles as potential anticancer agents.

Authors:  Imran Ali; Mohammad Nadeem Lone; Haasan Y Aboul-Enein
Journal:  Medchemcomm       Date:  2017-04-13       Impact factor: 3.597
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.