Literature DB >> 1575768

Mode of action of the antitumor compound girodazole (RP 49532A, NSC 627434).

G Colson1, B Rabault, F Lavelle, A Zerial.   

Abstract

Girodazole (RP 49532A) or 3-amino-1-[4-(2 amino-1H-imidazolyl]-propanol, 2HCl is an experimental antitumor compound which inhibits protein synthesis in cell cultures and in cell free systems. The compound has been evaluated for its capacity to inhibit specific assays of initiation, elongation and termination of protein synthesis. Girodazole inhibited the release of nascent peptides from polyribosomes in rabbit reticulocyte lysates indicating that the major effect of the compound is on the protein synthesis termination step.

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Year:  1992        PMID： 1575768     DOI： 10.1016/0006-2952(92)90701-j

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  8 in total

1.  Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis.

Authors:  Shan-Yu Fung; Vladimir Sofiyev; Julia Schneiderman; Aaron F Hirschfeld; Rachel E Victor; Kate Woods; Jeff S Piotrowski; Raamesh Deshpande; Sheena C Li; Nicole J de Voogd; Chad L Myers; Charlie Boone; Raymond J Andersen; Stuart E Turvey
Journal:  ACS Chem Biol       Date:  2013-10-29       Impact factor: 5.100

Review 2.  Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids.

Authors:  Ali Al-Mourabit; Manuel A Zancanella; Supriya Tilvi; Daniel Romo
Journal:  Nat Prod Rep       Date:  2011-05-09       Impact factor: 13.423

3.  The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole.

Authors:  Susan J Schroeder; Gregor Blaha; Julian Tirado-Rives; Thomas A Steitz; Peter B Moore
Journal:  J Mol Biol       Date:  2007-02-07       Impact factor: 5.469

4.  One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

Authors:  D S Ermolat'ev; B Savaliya; A Shah; E Van der Eycken
Journal:  Mol Divers       Date:  2010-08-26       Impact factor: 2.943

Review 5.  Marine Natural Products from New Caledonia--A Review.

Authors:  Sofia-Eléna Motuhi; Mohamed Mehiri; Claude Elisabeth Payri; Stéphane La Barre; Stéphane Bach
Journal:  Mar Drugs       Date:  2016-03-16       Impact factor: 5.118

6.  CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.

Authors:  Kseniya A Lashkevich; Valeriya I Shlyk; Artem S Kushchenko; Vadim N Gladyshev; Elena Z Alkalaeva; Sergey E Dmitriev
Journal:  Biomolecules       Date:  2020-06-16

Review 7.  Marine sponges as pharmacy.

Authors:  Detmer Sipkema; Maurice C R Franssen; Ronald Osinga; Johannes Tramper; René H Wijffels
Journal:  Mar Biotechnol (NY)       Date:  2005-03-24       Impact factor: 3.619

Review 8.  A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis.

Authors:  S E Dmitriev; D O Vladimirov; K A Lashkevich
Journal:  Biochemistry (Mosc)       Date:  2020-11       Impact factor: 2.487
  8 in total

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