Literature DB >> 17134271

Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.

Denis S Ermolat'ev1, Eugene V Babaev, Erik V Van der Eycken.   

Abstract

A microwave-assisted, one-pot, two-step protocol was developed for the construction of polysubstituted 2-aminoimidazoles. This process involves the sequential formation of imidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and alpha-bromocarbonyl compounds, followed by opening of the pyrimidine ring with hydrazine. [reaction: see text]

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Year:  2006        PMID： 17134271     DOI： 10.1021/ol062421c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

2.  One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

Authors:  D S Ermolat'ev; B Savaliya; A Shah; E Van der Eycken
Journal:  Mol Divers       Date:  2010-08-26       Impact factor: 2.943

3.  Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities.

Authors:  Sachin G Modha; Vaibhav P Mehta; Denis Ermolat'ev; Jan Balzarini; Kristof Van Hecke; Luc Van Meervelt; Erik Van der Eycken
Journal:  Mol Divers       Date:  2010-01-19       Impact factor: 3.364

4.  Modulation of the Substitution Pattern of 5-Aryl-2-Aminoimidazoles Allows Fine-Tuning of Their Antibiofilm Activity Spectrum and Toxicity.

Authors:  Elien Peeters; Geert Hooyberghs; Stijn Robijns; Kai Waldrant; Ami De Weerdt; Nicolas Delattin; Veerle Liebens; Soňa Kucharíková; Hélène Tournu; Natalie Verstraeten; Barbara Dovgan; Lenart Girandon; Mirjam Fröhlich; Katrijn De Brucker; Patrick Van Dijck; Jan Michiels; Bruno P A Cammue; Karin Thevissen; Jozef Vanderleyden; Erik Van der Eycken; Hans P Steenackers
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191
  4 in total

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