Literature DB >> 20662649

Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.

Sarah R MacEwan1, Daniel J Callahan, Ashutosh Chilkoti.   

Abstract

Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in 'smart' - stimulus-responsive - peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.

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Year:  2010        PMID： 20662649      PMCID： PMC2963449          DOI： 10.2217/nnm.10.50

Source DB:  PubMed          Journal:  Nanomedicine (Lond)        ISSN： 1743-5889            Impact factor:   5.307


  92 in total

1.  Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system.

Authors:  Dan E Meyer; Ashutosh Chilkoti
Journal:  Biomacromolecules       Date:  2002 Mar-Apr       Impact factor: 6.988

2.  Liposomes from novel photolabile phospholipids: light-induced unloading of small molecules as monitored by PFG NMR.

Authors:  Yongqin Wan; Joseph K Angleson; Andrei G Kutateladze
Journal:  J Am Chem Soc       Date:  2002-05-22       Impact factor: 15.419

Review 3.  Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities.

Authors:  Go Saito; Joel A Swanson; Kyung-Dall Lee
Journal:  Adv Drug Deliv Rev       Date:  2003-02-10       Impact factor: 15.470

Review 4.  Water soluble polymers in tumor targeted delivery.

Authors:  J Kopecek; P Kopecková; T Minko; Z R Lu; C M Peterson
Journal:  J Control Release       Date:  2001-07-06       Impact factor: 9.776

5.  Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo.

Authors:  J W Singer; R Bhatt; J Tulinsky; K R Buhler; E Heasley; P Klein; P de Vries
Journal:  J Control Release       Date:  2001-07-06       Impact factor: 9.776

6.  Drug targeting using thermally responsive polymers and local hyperthermia.

Authors:  D E Meyer; B C Shin; G A Kong; M W Dewhirst; A Chilkoti
Journal:  J Control Release       Date:  2001-07-06       Impact factor: 9.776

7.  Development of the polymer micelle carrier system for doxorubicin.

Authors:  T Nakanishi; S Fukushima; K Okamoto; M Suzuki; Y Matsumura; M Yokoyama; T Okano; Y Sakurai; K Kataoka
Journal:  J Control Release       Date:  2001-07-06       Impact factor: 9.776

8.  Metalloprotease-specific poly(ethylene glycol) methyl ether-peptide-doxorubicin conjugate for targeting anticancer drug delivery based on angiogenesis.

Authors:  M Bae; S Cho; J Song; G Y Lee; K Kim; J Yang; K Cho; S Y Kim; Y Byun
Journal:  Drugs Exp Clin Res       Date:  2003

Review 9.  Microdialysis: an in vivo approach for measuring drug delivery in oncology.

Authors:  Martin Brunner; Markus Müller
Journal:  Eur J Clin Pharmacol       Date:  2002-05-23       Impact factor: 2.953

10.  Ultrasonically activated chemotherapeutic drug delivery in a rat model.

Authors:  Jared L Nelson; Beverly L Roeder; John C Carmen; Friederike Roloff; William G Pitt
Journal:  Cancer Res       Date:  2002-12-15       Impact factor: 12.701
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  34 in total

1.  Identification of reduced-order thermal therapy models using thermal MR images: theory and validation.

Authors:  Ran Niu; Mikhail Skliar
Journal:  IEEE Trans Med Imaging       Date:  2012-04-16       Impact factor: 10.048

2.  Direct Tracking of Particles and Quantification of Margination in Blood Flow.

Authors:  Erik J Carboni; Brice H Bognet; Grant M Bouchillon; Andrea L Kadilak; Leslie M Shor; Michael D Ward; Anson W K Ma
Journal:  Biophys J       Date:  2016-10-04       Impact factor: 4.033

3.  Digital switching of local arginine density in a genetically encoded self-assembled polypeptide nanoparticle controls cellular uptake.

Authors:  Sarah R Macewan; Ashutosh Chilkoti
Journal:  Nano Lett       Date:  2012-05-31       Impact factor: 11.189

Review 4.  Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer.

Authors:  Natalya Rapoport
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2012-06-22

Review 5.  Phase-shift, stimuli-responsive drug carriers for targeted delivery.

Authors:  Brian E O'Neill; Natalya Rapoport
Journal:  Ther Deliv       Date:  2011-09

6.  Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle.

Authors:  Marc P Kai; Amanda W Keeler; Jillian L Perry; Kevin G Reuter; J Christopher Luft; Sara K O'Neal; William C Zamboni; Joseph M DeSimone
Journal:  J Control Release       Date:  2015-03-03       Impact factor: 9.776

Review 7.  Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy.

Authors:  Beth Goins; William T Phillips; Ande Bao
Journal:  Expert Opin Drug Deliv       Date:  2016-04-04       Impact factor: 6.648

8.  Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging.

Authors:  Tatiana V Esipova; Alexander Karagodov; Joann Miller; David F Wilson; Theresa M Busch; Sergei A Vinogradov
Journal:  Anal Chem       Date:  2011-10-17       Impact factor: 6.986

9.  PLA2-responsive and SPIO-loaded phospholipid micelles.

Authors:  Qiang Gao; Lesan Yan; Michael Chiorazzo; E James Delikatny; Andrew Tsourkas; Zhiliang Cheng
Journal:  Chem Commun (Camb)       Date:  2015-08-07       Impact factor: 6.222

10.  Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy.

Authors:  Renata Jaskula-Sztul; Wenjin Xu; Guojun Chen; April Harrison; Ajitha Dammalapati; Renu Nair; Yiqiang Cheng; Shaoqin Gong; Herbert Chen
Journal:  Biomaterials       Date:  2016-03-08       Impact factor: 12.479
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