Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Development of the polymer micelle carrier system for doxorubicin.

Literature DB >> 11489509

Development of the polymer micelle carrier system for doxorubicin.

T Nakanishi¹, S Fukushima, K Okamoto, M Suzuki, Y Matsumura, M Yokoyama, T Okano, Y Sakurai, K Kataoka.

Abstract

We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated doxorubicin-polyaspartic acid. It has high hydrophobic inner core, and therefore can entrap the sufficient amount of DOX. NK911 has a small particle size of about 40 nm in diameter that accumulates in tumor tissue by EPR effect showing much stronger activity than the free DOX. We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2001 PMID： 11489509 DOI： 10.1016/s0168-3659(01)00341-8

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

Keyword Cloud
Cited

72 in total

1. In vivo evaluation of doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes (PolyDoxSome) using DMBA-induced mammary carcinoma rat model and comparison with marketed LipoDox™.

Authors: Wubeante Yenet Ayen; Neeraj Kumar
Journal: Pharm Res Date: 2012-06-06 Impact factor: 4.200

2. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors.

Authors: Yashveer Singh; Dayuan Gao; Zichao Gu; Shike Li; Stanley Stein; Patrick J Sinko
Journal: Mol Pharm Date: 2011-11-22 Impact factor: 4.939

Review 3. Utilization of monoclonal antibody-targeted nanomaterials in the treatment of cancer.

Authors: Daniel C Julien; Steven Behnke; Guankui Wang; Gordon K Murdoch; Rodney A Hill
Journal: MAbs Date: 2011-09-01 Impact factor: 5.857

Review 4. Enabling individualized therapy through nanotechnology.

Authors: Jason H Sakamoto; Anne L van de Ven; Biana Godin; Elvin Blanco; Rita E Serda; Alessandro Grattoni; Arturas Ziemys; Ali Bouamrani; Tony Hu; Shivakumar I Ranganathan; Enrica De Rosa; Jonathan O Martinez; Christine A Smid; Rachel M Buchanan; Sei-Young Lee; Srimeenakshi Srinivasan; Matthew Landry; Anne Meyn; Ennio Tasciotti; Xuewu Liu; Paolo Decuzzi; Mauro Ferrari
Journal: Pharmacol Res Date: 2010-01-05 Impact factor: 7.658

Review 5. Immunotherapeutic strategies to target prognostic and predictive markers of cancer.

Authors: Michael S Magee; Adam E Snook; Glen P Marszalowicz; Scott A Waldman
Journal: Biomark Med Date: 2013-02 Impact factor: 2.851

Review 6. Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs.

Authors: Avinash Gothwal; Iliyas Khan; Umesh Gupta
Journal: Pharm Res Date: 2015-09-17 Impact factor: 4.200

Review 7. Silicon micro- and nanofabrication for medicine.

Authors: Daniel Fine; Alessandro Grattoni; Randy Goodall; Shyam S Bansal; Ciro Chiappini; Sharath Hosali; Anne L van de Ven; Srimeenkashi Srinivasan; Xuewu Liu; Biana Godin; Louis Brousseau; Iman K Yazdi; Joseph Fernandez-Moure; Ennio Tasciotti; Hung-Jen Wu; Ye Hu; Steve Klemm; Mauro Ferrari
Journal: Adv Healthc Mater Date: 2013-04-15 Impact factor: 9.933

Development of the polymer micelle carrier system for doxorubicin.

1. In vivo evaluation of doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes (PolyDoxSome) using DMBA-induced mammary carcinoma rat model and comparison with marketed LipoDox™.

2. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors.

Review 3. Utilization of monoclonal antibody-targeted nanomaterials in the treatment of cancer.

Review 4. Enabling individualized therapy through nanotechnology.

Review 5. Immunotherapeutic strategies to target prognostic and predictive markers of cancer.

Review 6. Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs.

Review 7. Silicon micro- and nanofabrication for medicine.

8. Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)^☆.

Review 9. Nanovehicular intracellular delivery systems.

10. Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine).

Development of the polymer micelle carrier system for doxorubicin.

1. In vivo evaluation of doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes (PolyDoxSome) using DMBA-induced mammary carcinoma rat model and comparison with marketed LipoDox™.

2. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors.

Review 3. Utilization of monoclonal antibody-targeted nanomaterials in the treatment of cancer.

Review 4. Enabling individualized therapy through nanotechnology.

Review 5. Immunotherapeutic strategies to target prognostic and predictive markers of cancer.

Review 6. Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs.

Review 7. Silicon micro- and nanofabrication for medicine.

8. Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)☆.

Review 9. Nanovehicular intracellular delivery systems.

10. Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine).

8. Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)^☆.