Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Water soluble polymers in tumor targeted delivery.

Literature DB >> 11489491

Water soluble polymers in tumor targeted delivery.

J Kopecek¹, P Kopecková, T Minko, Z R Lu, C M Peterson.

Abstract

The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2001 PMID： 11489491 DOI： 10.1016/s0168-3659(01)00330-3

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

Keyword Cloud
Cited

33 in total

1. Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].

Authors: Hui Ding; Satoshi Inoue; Alexander V Ljubimov; Rameshwar Patil; Jose Portilla-Arias; Jinwei Hu; Bindu Konda; Kolja A Wawrowsky; Manabu Fujita; Natalya Karabalin; Takako Sasaki; Keith L Black; Eggehard Holler; Julia Y Ljubimova
Journal: Proc Natl Acad Sci U S A Date: 2010-10-04 Impact factor: 11.205

Review 2. Polymeric nanogel formulations of nucleoside analogs.

Authors: Serguei V Vinogradov
Journal: Expert Opin Drug Deliv Date: 2007-01 Impact factor: 6.648

Review 3. Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.

Authors: Lara Milane; Shanthi Ganesh; Shruti Shah; Zhen-Feng Duan; Mansoor Amiji
Journal: J Control Release Date: 2011-04-08 Impact factor: 9.776

4. Peptide-based Biopolymers in Biomedicine and Biotechnology.

Authors: Dominic Chow; Michelle L Nunalee; Dong Woo Lim; Andrew J Simnick; Ashutosh Chilkoti
Journal: Mater Sci Eng R Rep Date: 2008-01 Impact factor: 36.214

Review 5. Click chemistry, a powerful tool for pharmaceutical sciences.

Authors: Christopher D Hein; Xin-Ming Liu; Dong Wang
Journal: Pharm Res Date: 2008-05-29 Impact factor: 4.200

6. Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.

Authors: Chelsea D Landon; Ji-Young Park; David Needham; Mark W Dewhirst
Journal: Open Nanomed J Date: 2011-01-01

Water soluble polymers in tumor targeted delivery.

1. Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].

Review 2. Polymeric nanogel formulations of nucleoside analogs.

Review 3. Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.

4. Peptide-based Biopolymers in Biomedicine and Biotechnology.

Review 5. Click chemistry, a powerful tool for pharmaceutical sciences.

6. Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.

7. Synergistic antitumor activity of camptothecin-doxorubicin combinations and their conjugates with hyaluronic acid.

8. Temperature-sensitive magnetic drug carriers for concurrent gemcitabine chemohyperthermia.

9. Circumventing tumor resistance to chemotherapy by nanotechnology.

10. Evidence of oral translocation of anionic G6.5 dendrimers in mice.