| Literature DB >> 20657585 |
Morgan E Royce-Tolland1, Angela A Andersen, Hannah R Koyfman, Dale J Talbot, Anton Wutz, Ian D Tonks, Graham F Kay, Barbara Panning.
Abstract
One X chromosome, selected at random, is silenced in each female mammalian cell. Xist encodes a noncoding RNA that influences the probability that the cis-linked X chromosome will be silenced. We found that the A-repeat, a highly conserved element within Xist, is required for the accumulation of spliced Xist RNA. In addition, the A-repeat is necessary for X-inactivation to occur randomly. In combination, our data suggest that normal Xist RNA processing is important in the regulation of random X-inactivation. We propose that modulation of Xist RNA processing may be part of the stochastic process that determines which X chromosome will be inactivated.Entities:
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Year: 2010 PMID： 20657585 PMCID： PMC4336797 DOI： 10.1038/nsmb.1877
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369