Literature DB >> 6231885

Comparison of properties of woodchuck hepatitis virus and human hepatitis B virus endogenous DNA polymerases.

O Hantz, T Ooka, L Vitvitski, C Pichoud, C Trepo.   

Abstract

The principal properties of the DNA polymerases of woodchuck hepatitis virus and human hepatitis B virus were compared. The enzymes of both viruses exhibited optimal activities in the same range of pH, ionic strength, and MgCl2 concentration. Like human hepatitis B virus DNA polymerase, the woodchuck hepatitis virus DNA polymerase was strongly inhibited by phosphonoformic acid but not by phosphonoacetic acid and aphidicolin. Similar inhibition patterns for both enzymes were observed with arabinofuranosyl nucleotides (9-beta-D-arabinofuranosyladenine-5'-triphosphate, 1-beta-D-arabinofuranosylcytosine-5'-triphosphate, 1-beta-D-arabinofuranosylthymine-5'-triphosphate) and dideoxythymidine triphosphate, whereas no effect was obtained with corresponding nucleosides. The therapeutic significance of these results and the relevance of the woodchuck as an experimental animal model for the study of human hepatitis B virus infections are discussed.

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Year:  1984        PMID： 6231885      PMCID： PMC185482          DOI： 10.1128/AAC.25.2.242

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles.

Authors:  J Summers; A O'Connell; I Millman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

Review 3.  Eukaryotic DNA polymerases.

Authors:  A Weissbach
Journal:  Annu Rev Biochem       Date:  1977       Impact factor: 23.643

4.  Radioimmunoassay for the detection of the core of the Dane particle and antibody to it.

Authors:  R H Purcell; J L Gerin; J B Almeida; P V Holland
Journal:  Intervirology       Date:  1974       Impact factor: 1.763

5.  Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 9-beta-D-arabinofuranosyladenine.

Authors:  J J Furth; S S Cohen
Journal:  Cancer Res       Date:  1967-09       Impact factor: 12.701

6.  Inhibition of hepatitis B DNA polymerase by intercalating agents.

Authors:  S Z Hirschman; E Garfinkel
Journal:  Nature       Date:  1978-02-16       Impact factor: 49.962

7.  Effect of vidarabine on chronic hepatitis B virus infection.

Authors:  R B Pollard; J L Smith; A Neal; P B Gregory; T C Merigan; W S Robinson
Journal:  JAMA       Date:  1978-04-21       Impact factor: 56.272

8.  Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.

Authors:  J F Aswell; G P Allen; A T Jamieson; D E Campbell; G A Gentry
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

9.  Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

Authors:  J J Furth; S S Cohen
Journal:  Cancer Res       Date:  1968-10       Impact factor: 12.701

10.  DNA polymerase associated with human hepatitis B antigen.

Authors:  P M Kaplan; R L Greenman; J L Gerin; R H Purcell; W S Robinson
Journal:  J Virol       Date:  1973-11       Impact factor: 5.103
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  9 in total

1.  Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.

Authors:  P Rajagopalan; F D Boudinot; C K Chu; B C Tennant; B H Baldwin; R F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

2.  Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.

Authors:  D F Smee; S S Knight; A E Duke; W S Robinson; T R Matthews; P L Marion
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

3.  Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity.

Authors:  J Köck; H J Schlicht
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

4.  Detection of HBs antigen, DNA polymerase activity, and hepatitis B virus DNA in tears: relevance to hepatitis B transmission by tears.

Authors:  P Gastaud; C Baudouin; D Ouzan
Journal:  Br J Ophthalmol       Date:  1989-05       Impact factor: 4.638

5.  Antiviral activity of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus.

Authors:  F Le Guerhier; C Pichoud; C Jamard; S Guerret; M Chevallier; S Peyrol; O Hantz; I King; C Trépo; Y C Cheng; F Zoulim
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

6.  In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks.

Authors:  J M Cullen; S L Smith; M G Davis; S E Dunn; C Botteron; A Cecchi; D Linsey; D Linzey; L Frick; M T Paff; A Goulding; K Biron
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

7.  Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies.

Authors:  P S Venkateswaran; I Millman; B S Blumberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

8.  Treatment of polyarteritis nodosa related to hepatitis B virus with interferon-alpha and plasma exchanges.

Authors:  L Guillevin; F Lhote; F Sauvaget; P Deblois; F Rossi; D Levallois; J Pourrat; B Christoforov; C Trépo
Journal:  Ann Rheum Dis       Date:  1994-05       Impact factor: 19.103

9.  Callus induction in Phyllanthus species and inhibition of viral DNA polymerase and reverse transcriptase by callus extracts.

Authors:  D W Unander
Journal:  Plant Cell Rep       Date:  1991-11       Impact factor: 4.570
  9 in total

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