Literature DB >> 20588318

Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging.

Ralph E Hurd1, Yi-Fen Yen, James Tropp, Adolf Pfefferbaum, Daniel M Spielman, Dirk Mayer.   

Abstract

Dynamic hyperpolarized [1-(13)C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner. A 12-second bolus injection of hyperpolarized [1-(13)C]pyruvate is imaged at a 3-second temporal resolution. The observed dynamics are evaluated with regard to cerebral blood volume (CBV), flow, transport, and metabolic exchange with the cerebral lactate pool. A model for brain [1-(13)C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described.

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Year:  2010        PMID： 20588318      PMCID： PMC2975615          DOI： 10.1038/jcbfm.2010.93

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  21 in total

1.  Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.

Authors:  Ralph E Hurd; Yi-Fen Yen; Dirk Mayer; Albert Chen; David Wilson; Susan Kohler; Robert Bok; Daniel Vigneron; John Kurhanewicz; James Tropp; Daniel Spielman; Adolf Pfefferbaum
Journal:  Magn Reson Med       Date:  2010-05       Impact factor: 4.668

2.  Autoradiographic measurement of cerebral lactate transport rate constants in normal and activated conditions.

Authors:  J L Lear; R K Kasliwal
Journal:  J Cereb Blood Flow Metab       Date:  1991-07       Impact factor: 6.200

3.  Gradient-Echo Imaging Considerations for Hyperpolarized 129Xe MR

Authors: 
Journal:  J Magn Reson B       Date:  1996-11

4.  Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice.

Authors:  Matthew L Zierhut; Yi-Fen Yen; Albert P Chen; Robert Bok; Mark J Albers; Vickie Zhang; Jim Tropp; Ilwoo Park; Daniel B Vigneron; John Kurhanewicz; Ralph E Hurd; Sarah J Nelson
Journal:  J Magn Reson       Date:  2009-10-13       Impact factor: 2.229

5.  Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats.

Authors:  J E Cremer; V J Cunningham; W M Pardridge; L D Braun; W H Oldendorf
Journal:  J Neurochem       Date:  1979-08       Impact factor: 5.372

6.  Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.

Authors:  Christopher S Ward; Humsa S Venkatesh; Myriam M Chaumeil; Alissa H Brandes; Mark Vancriekinge; Hagit Dafni; Subramaniam Sukumar; Sarah J Nelson; Daniel B Vigneron; John Kurhanewicz; C David James; Daphne A Haas-Kogan; Sabrina M Ronen
Journal:  Cancer Res       Date:  2010-02-09       Impact factor: 12.701

7.  A p.m.r. isotope-exchange method for studying the kinetic properties of dehydrogenases in intact cells.

Authors:  R J Simpson; K M Brindle; F F Brown; I D Campbell; D L Foxall
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

8.  In vivo 13C saturation transfer effect of the lactate dehydrogenase reaction.

Authors:  Su Xu; Jehoon Yang; Jun Shen
Journal:  Magn Reson Med       Date:  2007-02       Impact factor: 4.668

9.  Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.

Authors:  Klaes Golman; René In't Zandt; Mathilde Lerche; Rikard Pehrson; Jan Henrik Ardenkjaer-Larsen
Journal:  Cancer Res       Date:  2006-11-15       Impact factor: 12.701

10.  Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Authors:  Sam E Day; Mikko I Kettunen; Ferdia A Gallagher; De-En Hu; Mathilde Lerche; Jan Wolber; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Kevin M Brindle
Journal:  Nat Med       Date:  2007-10-28       Impact factor: 53.440
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  28 in total

Review 1.  Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.

Authors:  Lydia M Le Page; Caroline Guglielmetti; Celine Taglang; Myriam M Chaumeil
Journal:  Trends Neurosci       Date:  2020-04-08       Impact factor: 13.837

2.  Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging.

Authors:  Tim R Eichhorn; Yuhei Takado; Najat Salameh; Andrea Capozzi; Tian Cheng; Jean-Noël Hyacinthe; Mor Mishkovsky; Christophe Roussel; Arnaud Comment
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-21       Impact factor: 11.205

3.  Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging.

Authors:  Eugen Kubala; Kim A Muñoz-Álvarez; Geoffrey Topping; Christian Hundshammer; Benedikt Feuerecker; Pedro A Gómez; Giorgio Pariani; Franz Schilling; Steffen J Glaser; Rolf F Schulte; Marion I Menzel; Markus Schwaiger
Journal:  J Vis Exp       Date:  2016-12-30       Impact factor: 1.355

4.  A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates.

Authors:  Peder E Z Larson; Adam B Kerr; Christine Leon Swisher; John M Pauly; Daniel B Vigneron
Journal:  J Magn Reson       Date:  2012-10-17       Impact factor: 2.229

5.  Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C magnetic resonance spectroscopic imaging.

Authors:  Sadia A Butt; Lise V Søgaard; Peter O Magnusson; Mette H Lauritzen; Christoffer Laustsen; Per Åkeson; Jan H Ardenkjær-Larsen
Journal:  J Cereb Blood Flow Metab       Date:  2012-03-28       Impact factor: 6.200

6.  Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate.

Authors:  Sonal Josan; Daniel Spielman; Yi-Fen Yen; Ralph Hurd; Adolf Pfefferbaum; Dirk Mayer
Journal:  NMR Biomed       Date:  2012-02-14       Impact factor: 4.044

7.  Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging.

Authors:  Jae Mo Park; Lawrence D Recht; Sonal Josan; Milton Merchant; Taichang Jang; Yi-Fen Yen; Ralph E Hurd; Daniel M Spielman; Dirk Mayer
Journal:  Neuro Oncol       Date:  2013-01-17       Impact factor: 12.300

8.  Hyperpolarized (13)C-lactate to (13)C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment.

Authors:  Jae Mo Park; Daniel M Spielman; Sonal Josan; Taichang Jang; Milton Merchant; Ralph E Hurd; Dirk Mayer; Lawrence D Recht
Journal:  NMR Biomed       Date:  2016-03-14       Impact factor: 4.044

9.  Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate.

Authors:  Jae Mo Park; Sonal Josan; Thomas Grafendorfer; Yi-Fen Yen; Ralph E Hurd; Daniel M Spielman; Dirk Mayer
Journal:  NMR Biomed       Date:  2013-04-02       Impact factor: 4.044

10.  Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate.

Authors:  Jae Mo Park; Sonal Josan; Taichang Jang; Milton Merchant; Yi-Fen Yen; Ralph E Hurd; Lawrence Recht; Daniel M Spielman; Dirk Mayer
Journal:  Magn Reson Med       Date:  2012-02-14       Impact factor: 4.668
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