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Literature DB >> 22453630

Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C magnetic resonance spectroscopic imaging.

Sadia A Butt¹, Lise V Søgaard, Peter O Magnusson, Mette H Lauritzen, Christoffer Laustsen, Per Åkeson, Jan H Ardenkjær-Larsen.

Abstract

The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-(13)C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1-(13)C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease.

Entities: Chemical Disease Species

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Year: 2012 PMID： 22453630 PMCID： PMC3421087 DOI： 10.1038/jcbfm.2012.34

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

47 in total

1. Effect of alpha-ketoisocaproate and leucine on the in vivo oxidation of glutamate and glutamine in the rat brain.

Authors: H R Zielke; Y Huang; P J Baab; R M Collins; C L Zielke; J T Tildon
Journal: Neurochem Res Date: 1997-09 Impact factor: 3.996

2. Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures.

Authors: V Erakovic; G Zupan; J Varljen; J Laginja; A Simonic
Journal: Epilepsia Date: 2001-02 Impact factor: 5.864

3. In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate.

Authors: Małgorzata Marjańska; Isabelle Iltis; Alexander A Shestov; Dinesh K Deelchand; Christopher Nelson; Kâmil Uğurbil; Pierre-Gilles Henry
Journal: J Magn Reson Date: 2010-07-16 Impact factor: 2.229

4. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.

Authors: Nader D Halim; Thomas Mcfate; Ahmed Mohyeldin; Peter Okagaki; Lioubov G Korotchkina; Mulchand S Patel; Nam Ho Jeoung; Robert A Harris; Michael J Schell; Ajay Verma
Journal: Glia Date: 2010-08 Impact factor: 7.452

5. Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study.

Authors: Tobias Horn; Jochen Klein
Journal: Neurochem Int Date: 2010-10-07 Impact factor: 3.921

6. Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

Authors: Magnus Karlsson; Pernille R Jensen; René in 't Zandt; Anna Gisselsson; Georg Hansson; Jens Ø Duus; Sebastian Meier; Mathilde H Lerche
Journal: Int J Cancer Date: 2010-08-01 Impact factor: 7.396

7. Astrocyte leucine metabolism: significance of branched-chain amino acid transamination.

Authors: M Yudkoff; Y Daikhin; L Grunstein; I Nissim; J Stern; D Pleasure; I Nissim
Journal: J Neurochem Date: 1996-01 Impact factor: 5.372

8. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Authors: Sam E Day; Mikko I Kettunen; Ferdia A Gallagher; De-En Hu; Mathilde Lerche; Jan Wolber; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Kevin M Brindle
Journal: Nat Med Date: 2007-10-28 Impact factor: 53.440

9. Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate.

Authors: Y-F Yen; S J Kohler; A P Chen; J Tropp; R Bok; J Wolber; M J Albers; K A Gram; M L Zierhut; I Park; V Zhang; S Hu; S J Nelson; D B Vigneron; J Kurhanewicz; H A A M Dirven; R E Hurd
Journal: Magn Reson Med Date: 2009-07 Impact factor: 4.668

10. Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

Authors: V Ibáñez; P Pietrini; G E Alexander; M L Furey; D Teichberg; J C Rajapakse; S I Rapoport; M B Schapiro; B Horwitz
Journal: Neurology Date: 1998-06 Impact factor: 9.910

17 in total

Review 1. Imaging Brain Metabolism Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy.

Authors: Lydia M Le Page; Caroline Guglielmetti; Celine Taglang; Myriam M Chaumeil
Journal: Trends Neurosci Date: 2020-04-08 Impact factor: 13.837

2. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

Authors: Ilwoo Park; Peder E Z Larson; Jeremy W Gordon; Lucas Carvajal; Hsin-Yu Chen; Robert Bok; Mark Van Criekinge; Marcus Ferrone; James B Slater; Duan Xu; John Kurhanewicz; Daniel B Vigneron; Susan Chang; Sarah J Nelson
Journal: Magn Reson Med Date: 2018-01-10 Impact factor: 4.668

3. The feasibility of assessing branched-chain amino acid metabolism in cellular models of prostate cancer with hyperpolarized [1-(13)C]-ketoisocaproate.

Authors: Kelvin L Billingsley; Jae Mo Park; Sonal Josan; Ralph Hurd; Dirk Mayer; Eleanor Spielman-Sun; Dwight G Nishimura; James D Brooks; Daniel Spielman
Journal: Magn Reson Imaging Date: 2014-04-28 Impact factor: 2.546

4. Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging.

Authors: Jae Mo Park; Lawrence D Recht; Sonal Josan; Milton Merchant; Taichang Jang; Yi-Fen Yen; Ralph E Hurd; Daniel M Spielman; Dirk Mayer
Journal: Neuro Oncol Date: 2013-01-17 Impact factor: 12.300

9. (13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging.

Authors: Lucia Salamanca-Cardona; Kayvan R Keshari
Journal: Cancer Metab Date: 2015-09-14

Review 10. (13)C NMR spectroscopy applications to brain energy metabolism.

Authors: Tiago B Rodrigues; Julien Valette; Anne-Karine Bouzier-Sore
Journal: Front Neuroenergetics Date: 2013-12-09

Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C magnetic resonance spectroscopic imaging.

1. Effect of alpha-ketoisocaproate and leucine on the in vivo oxidation of glutamate and glutamine in the rat brain.

2. Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures.

3. In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate.

4. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.

5. Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study.

6. Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

7. Astrocyte leucine metabolism: significance of branched-chain amino acid transamination.

8. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

9. Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate.

10. Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

Review 1. Imaging Brain Metabolism Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy.

2. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

3. The feasibility of assessing branched-chain amino acid metabolism in cellular models of prostate cancer with hyperpolarized [1-(13)C]-ketoisocaproate.

4. Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging.

Review 5. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

6. Effects of isoflurane anesthesia on hyperpolarized (13)C metabolic measurements in rat brain.

7. In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

Review 8. Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.

9. (13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging.

Review 10. (13)C NMR spectroscopy applications to brain energy metabolism.

Review 1. Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.

Review 5. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

Review 8. Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.

Review 10. (13)C NMR spectroscopy applications to brain energy metabolism.

Review 1. Imaging Brain Metabolism Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy.