Literature DB >> 32353337

Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.

Lydia M Le Page1, Caroline Guglielmetti1, Celine Taglang1, Myriam M Chaumeil2.   

Abstract

Aberrant metabolism is a key factor in many neurological disorders. The ability to measure such metabolic impairment could lead to improved detection of disease progression, and development and monitoring of new therapeutic approaches. Hyperpolarized 13C magnetic resonance spectroscopy (MRS) is a developing imaging technique that enables non-invasive measurement of enzymatic activity in real time in living organisms. Primarily applied in the fields of cancer and cardiac disease so far, this metabolic imaging method has recently been used to investigate neurological disorders. In this review, we summarize the preclinical research developments in this emerging field, and discuss future prospects for this exciting technology, which has the potential to change the clinical paradigm for patients with neurological disorders. Published by Elsevier Ltd.

Entities:  

Keywords:  MRI; clinical translation; hyperpolarized (13)C magnetic resonance spectroscopy; immunometabolism; metabolic imaging; neurological disorders; preclinical models

Year:  2020        PMID： 32353337      PMCID： PMC7255622          DOI： 10.1016/j.tins.2020.03.006

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  67 in total

1.  Intracerebral synthesis of glutamine from hyperpolarized glutamate.

Authors:  Leslie Mazuel; Rolf F Schulte; Aurélie Cladière; Claudine Spéziale; Marie Lagrée; Martin Leremboure; Betty Jean; Franck Durif; Carine Chassain
Journal:  Magn Reson Med       Date:  2016-11-08       Impact factor: 4.668

2.  Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

Authors:  Ilwoo Park; Peder E Z Larson; Jeremy W Gordon; Lucas Carvajal; Hsin-Yu Chen; Robert Bok; Mark Van Criekinge; Marcus Ferrone; James B Slater; Duan Xu; John Kurhanewicz; Daniel B Vigneron; Susan Chang; Sarah J Nelson
Journal:  Magn Reson Med       Date:  2018-01-10       Impact factor: 4.668

3.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR.

Authors:  Jan H Ardenkjaer-Larsen; Björn Fridlund; Andreas Gram; Georg Hansson; Lennart Hansson; Mathilde H Lerche; Rolf Servin; Mikkel Thaning; Klaes Golman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-20       Impact factor: 11.205

4.  Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain.

Authors:  Ilwoo Park; Peder E Z Larson; James L Tropp; Lucas Carvajal; Galen Reed; Robert Bok; Fraser Robb; John Bringas; Adrian Kells; Philip Pivirotto; Krystof Bankiewicz; Daniel B Vigneron; Sarah J Nelson
Journal:  Magn Reson Med       Date:  2013-11-11       Impact factor: 4.668

5.  Evidence for brain glucose dysregulation in Alzheimer's disease.

Authors:  Yang An; Vijay R Varma; Sudhir Varma; Ramon Casanova; Eric Dammer; Olga Pletnikova; Chee W Chia; Josephine M Egan; Luigi Ferrucci; Juan Troncoso; Allan I Levey; James Lah; Nicholas T Seyfried; Cristina Legido-Quigley; Richard O'Brien; Madhav Thambisetty
Journal:  Alzheimers Dement       Date:  2017-10-19       Impact factor: 21.566

6.  Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

Authors:  Sarah E Bohndiek; Mikko I Kettunen; De-en Hu; Brett W C Kennedy; Joan Boren; Ferdia A Gallagher; Kevin M Brindle
Journal:  J Am Chem Soc       Date:  2011-07-08       Impact factor: 15.419

7.  Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet.

Authors:  Young-Suk Choi; Somang Kang; Sang-Yoon Ko; Saeram Lee; Jae Young Kim; Hansol Lee; Jae Eun Song; Dong-Hyun Kim; Eosu Kim; Chul Hoon Kim; Lisa Saksida; Ho-Taek Song; Jong Eun Lee
Journal:  Mol Brain       Date:  2018-12-18       Impact factor: 4.041

Review 8.  In Vivo Imaging of Human Neuroinflammation.

Authors:  Daniel S Albrecht; Cristina Granziera; Jacob M Hooker; Marco L Loggia
Journal:  ACS Chem Neurosci       Date:  2016-03-25       Impact factor: 4.418

9.  Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance.

Authors:  Mor Mishkovsky; Brian Anderson; Magnus Karlsson; Mathilde H Lerche; A Dean Sherry; Rolf Gruetter; Zoltan Kovacs; Arnaud Comment
Journal:  Sci Rep       Date:  2017-09-15       Impact factor: 4.379

10.  13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Authors:  Jack J Miller; James T Grist; Sébastien Serres; James R Larkin; Angus Z Lau; Kevin Ray; Katherine R Fisher; Esben Hansen; Rasmus Stilling Tougaard; Per Mose Nielsen; Jakob Lindhardt; Christoffer Laustsen; Ferdia A Gallagher; Damian J Tyler; Nicola Sibson
Journal:  Sci Rep       Date:  2018-10-10       Impact factor: 4.379
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  12 in total

Review 1.  In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease.

Authors:  Rimil Guha Roy; Avantika Samkaria; Pravat K Mandal; Joseph C Maroon; Yashika Arora
Journal:  Neurochem Res       Date:  2022-01-28       Impact factor: 3.996

2.  Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-13C]pyruvate MRI.

Authors:  Nikolaj Bøgh; Christoffer Laustsen; Esben S S Hansen; Hatice Tankisi; Lotte B Bertelsen; Jakob U Blicher
Journal:  Tomography       Date:  2022-06-14

Review 3.  Molecular Sensing with Host Systems for Hyperpolarized 129Xe.

Authors:  Jabadurai Jayapaul; Leif Schröder
Journal:  Molecules       Date:  2020-10-11       Impact factor: 4.411

4.  Heterogeneous 1 H and 13 C Parahydrogen-Induced Polarization of Acetate and Pyruvate Esters.

Authors:  Oleg G Salnikov; Nikita V Chukanov; Larisa M Kovtunova; Valerii I Bukhtiyarov; Kirill V Kovtunov; Roman V Shchepin; Igor V Koptyug; Eduard Y Chekmenev
Journal:  Chemphyschem       Date:  2021-05-28       Impact factor: 3.520

Review 5.  Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging.

Authors:  Yan Li; Daniel B Vigneron; Duan Xu
Journal:  Eur J Nucl Med Mol Imaging       Date:  2021-08-25       Impact factor: 9.236

Review 6.  Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging.

Authors:  Nicholas R W Cleland; Saif I Al-Juboori; Evgenia Dobrinskikh; Kimberley D Bruce
Journal:  J Neuroinflammation       Date:  2021-10-28       Impact factor: 8.322

7.  Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo.

Authors:  Yutaro Saito; Hiroyuki Yatabe; Iori Tamura; Yohei Kondo; Ryo Ishida; Tomohiro Seki; Keita Hiraga; Akihiro Eguchi; Yoichi Takakusagi; Keisuke Saito; Nobu Oshima; Hiroshi Ishikita; Kazutoshi Yamamoto; Murali C Krishna; Shinsuke Sando
Journal:  Sci Adv       Date:  2022-03-30       Impact factor: 14.136

8.  LDH and PDH Activities in the Ischemic Brain and the Effect of Reperfusion-An Ex Vivo MR Study in Rat Brain Slices Using Hyperpolarized [1-13C]Pyruvate.

Authors:  Gal Sapir; David Shaul; Naama Lev-Cohain; Jacob Sosna; Moshe J Gomori; Rachel Katz-Brull
Journal:  Metabolites       Date:  2021-03-30

9.  Measuring Glycolytic Activity with Hyperpolarized [2H7, U-13C6] D-Glucose in the Naive Mouse Brain under Different Anesthetic Conditions.

Authors:  Emmanuelle Flatt; Bernard Lanz; Yves Pilloud; Andrea Capozzi; Mathilde Hauge Lerche; Rolf Gruetter; Mor Mishkovsky
Journal:  Metabolites       Date:  2021-06-23

10.  Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using Hyperpolarized 13C MRS of Pyruvate and DHA at 1.47 Tesla.

Authors:  Kai Qiao; Lydia M Le Page; Myriam M Chaumeil
Journal:  Metabolites       Date:  2021-06-22
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