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Literature DB >> 20432284

Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.

Ralph E Hurd¹, Yi-Fen Yen, Dirk Mayer, Albert Chen, David Wilson, Susan Kohler, Robert Bok, Daniel Vigneron, John Kurhanewicz, James Tropp, Daniel Spielman, Adolf Pfefferbaum.

Abstract

Formulation, polarization, and dissolution conditions were developed to obtain a stable hyperpolarized solution of [1-(13)C]-ethyl pyruvate. A maximum tolerated concentration and injection rate were determined, and (13)C spectroscopic imaging was used to compare the uptake of hyperpolarized [1-(13)C]-ethyl pyruvate relative to hyperpolarized [1-(13)C]-pyruvate into anesthetized rat brain. Hyperpolarized [1-(13)C]-ethyl pyruvate and [1-(13)C]-pyruvate metabolic imaging in normal brain is demonstrated and quantified in this feasibility and range-finding study. (c) 2010 Wiley-Liss, Inc.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20432284 PMCID： PMC2890241 DOI： 10.1002/mrm.22364

Source DB: PubMed Journal: Magn Reson Med ISSN： 0740-3194 Impact factor: 4.668

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Authors: M P Fink
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4. Toward Production of Pure ¹³C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-¹³C]acetate.

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Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.

1. Autoradiographic measurement of cerebral lactate transport rate constants in normal and activated conditions.

2. Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats.

3. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window.

Review 4. Brain metabolism: a perspective from the blood-brain barrier.

5. Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.

6. Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat.

7. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.

Review 8. Ethyl pyruvate: a novel anti-inflammatory agent.

9. A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass.

10. Regional kinetic constants for blood-brain barrier pyruvic acid transport in conscious rats by the monocarboxylic acid carrier.

1. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate.

Review 2. Imaging Brain Metabolism Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy.

3. Non-invasive in vivo assessment of IDH1 mutational status in glioma.

4. Toward Production of Pure ¹³C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-¹³C]acetate.

5. Parahydrogen-Induced Polarization of 1-¹³C-Acetates and 1-¹³C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters.

6. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Review 7. Probing carbohydrate metabolism using hyperpolarized ¹³ C-labeled molecules.

8. Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat.

9. A New Horizon of DNP technology: Application to In-vivo ¹³C Magnetic Resonance Spectroscopy and Imaging.

10. Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo.

Review 4. Brain metabolism: a perspective from the blood-brain barrier.

Review 8. Ethyl pyruvate: a novel anti-inflammatory agent.

Review 2. Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.

Review 7. Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

Review 2. Imaging Brain Metabolism Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy.

Review 7. Probing carbohydrate metabolism using hyperpolarized ¹³ C-labeled molecules.