OBJECTIVE: To investigate the role of diffusion-weighted imaging (DWI) in predicting and monitoring chemoradiotherapy response in head and neck squamous cell carcinoma (HNSCC). METHODS: Diffusion-weighted imaging was performed pre-treatment (n = 50), intra-treatment (n = 41) and post-treatment (n = 20). Apparent diffusion coefficient (ADC) values were correlated with locoregional failure (LF). RESULTS: Locoregional failure occurred in 20/50 (40%) patients. A significant correlation was found between LF and post-treatment ADC (p = 0.02) but not pre- or intra-treatment ADC. Serial change in ADC was even more significant (p = 0.00001), using a fall in ADC early (pre- to intra-treatment) or late (intra- to post-treatment) to indicate LF, achieved 100% specificity, 80% sensitivity and 90% accuracy. CONCLUSIONS: Single ADC measurements pre- or intra-treatment did not predict response, but ADC post-treatment was a marker for LF. Serial change in ADC was an even stronger marker, when using an early or late treatment fall in ADC to identify LF.
OBJECTIVE: To investigate the role of diffusion-weighted imaging (DWI) in predicting and monitoring chemoradiotherapy response in head and neck squamous cell carcinoma (HNSCC). METHODS: Diffusion-weighted imaging was performed pre-treatment (n = 50), intra-treatment (n = 41) and post-treatment (n = 20). Apparent diffusion coefficient (ADC) values were correlated with locoregional failure (LF). RESULTS:Locoregional failure occurred in 20/50 (40%) patients. A significant correlation was found between LF and post-treatment ADC (p = 0.02) but not pre- or intra-treatment ADC. Serial change in ADC was even more significant (p = 0.00001), using a fall in ADC early (pre- to intra-treatment) or late (intra- to post-treatment) to indicate LF, achieved 100% specificity, 80% sensitivity and 90% accuracy. CONCLUSIONS: Single ADC measurements pre- or intra-treatment did not predict response, but ADC post-treatment was a marker for LF. Serial change in ADC was an even stronger marker, when using an early or late treatment fall in ADC to identify LF.
Authors: Vincent Vandecaveye; Frederik De Keyzer; Sandra Nuyts; Karen Deraedt; Piet Dirix; Pascal Hamaekers; Vincent Vander Poorten; Pierre Delaere; Robert Hermans Journal: Int J Radiat Oncol Biol Phys Date: 2006-12-04 Impact factor: 7.038
Authors: Harriet C Thoeny; Frederik De Keyzer; Feng Chen; Vincent Vandecaveye; Erik K Verbeken; Bisan Ahmed; Xihe Sun; Yicheng Ni; Hilde Bosmans; Robert Hermans; Allan van Oosterom; Guy Marchal; Willy Landuyt Journal: Neoplasia Date: 2005-08 Impact factor: 5.715
Authors: J Wang; S Takashima; F Takayama; S Kawakami; A Saito; T Matsushita; M Momose; T Ishiyama Journal: Radiology Date: 2001-09 Impact factor: 11.105
Authors: Sungheon Kim; Laurie Loevner; Harry Quon; Eric Sherman; Gregory Weinstein; Alex Kilger; Harish Poptani Journal: Clin Cancer Res Date: 2009-02-01 Impact factor: 12.531
Authors: John W Rogers; Kathryn M Greven; W Frederick McGuirt; John W Keyes; Dan W Williams; Nat E Watson; Kim Geisinger; James O Cappellari Journal: Int J Radiat Oncol Biol Phys Date: 2004-03-01 Impact factor: 7.038
Authors: Vincent Vandecaveye; Frederik De Keyzer; Vincent Vander Poorten; Piet Dirix; Eric Verbeken; Sandra Nuyts; Robert Hermans Journal: Radiology Date: 2009-02-27 Impact factor: 11.105
Authors: C S Schouten; P de Graaf; E Bloemena; B I Witte; B J M Braakhuis; R H Brakenhoff; C R Leemans; J A Castelijns; R de Bree Journal: AJNR Am J Neuroradiol Date: 2015-02-26 Impact factor: 3.825
Authors: M Hatakenaka; Y Shioyama; K Nakamura; H Yabuuchi; Y Matsuo; S Sunami; T Kamitani; T Yoshiura; T Nakashima; K Nishikawa; H Honda Journal: AJNR Am J Neuroradiol Date: 2011-07-21 Impact factor: 3.825