Literature DB >> 20217481

Should non-invasiveness change informed consent procedures for prenatal diagnosis?

Zuzana Deans1, Ainsley J Newson.   

Abstract

Empirical evidence suggests that some health professionals believe consent procedures for the emerging technology of non-invasive prenatal diagnosis (NIPD) should become less rigorous than those currently used for invasive prenatal testing. In this paper, we consider the importance of informed consent and informed choice procedures for protecting autonomy in those prenatal tests which will give rise to a definitive result. We consider whether there is anything special about NIPD that could sanction a change to consent procedures for prenatal diagnosis or otherwise render informed decision-making less important. We accept the claim that the absence of risk of miscarriage to some extent lessens the gravity of the decision to test compared with invasive methods of testing. However, we also claim that the definitive nature of the information received, and the fact that the information can lead to decisions of great significance, makes NIPD an important choice. This choice should only be made by means of a rigorous and appropriately supported decision-making process (assuming that this is what the pregnant woman wants). We conclude that, on balance, consent procedures for NIPD should mirror those for invasive testing, albeit without the need to emphasise procedure-related risk.

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Year:  2011        PMID: 20217481     DOI: 10.1007/s10728-010-0146-8

Source DB:  PubMed          Journal:  Health Care Anal        ISSN: 1065-3058


  15 in total

Review 1.  Ethical aspects arising from non-invasive fetal diagnosis.

Authors:  Ainsley J Newson
Journal:  Semin Fetal Neonatal Med       Date:  2008-04       Impact factor: 3.926

Review 2.  The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis.

Authors:  Caroline F Wright; Hilary Burton
Journal:  Hum Reprod Update       Date:  2008-10-22       Impact factor: 15.610

3.  An offer you can't refuse? Ethical implications of non-invasive prenatal diagnosis.

Authors:  Dagmar Schmitz; Christian Netzer; Wolfram Henn
Journal:  Nat Rev Genet       Date:  2009-08       Impact factor: 53.242

Review 4.  Cell-free fetal DNA and RNA in maternal blood: implications for safer antenatal testing.

Authors:  Caroline F Wright; Lyn S Chitty
Journal:  BMJ       Date:  2009-07-06

Review 5.  Noninvasive prenatal diagnosis: current practice and future perspectives.

Authors:  Sinuhe Hahn; Lyn S Chitty
Journal:  Curr Opin Obstet Gynecol       Date:  2008-04       Impact factor: 1.927

6.  Will the introduction of non-invasive prenatal diagnostic testing erode informed choices? An experimental study of health care professionals.

Authors:  Ananda van den Heuvel; Lyn Chitty; Elizabeth Dormandy; Ainsley Newson; Zuzana Deans; Sophie Attwood; Shelley Haynes; Theresa M Marteau
Journal:  Patient Educ Couns       Date:  2009-06-26

7.  Reconsidering prenatal screening: an empirical-ethical approach to understand moral dilemmas as a question of personal preferences.

Authors:  E García; D R M Timmermans; E van Leeuwen
Journal:  J Med Ethics       Date:  2009-07       Impact factor: 2.903

8.  Risk, autonomy, and responsibility. Informed consent for prenatal testing.

Authors:  N Press; C H Browner
Journal:  Hastings Cent Rep       Date:  1995 May-Jun       Impact factor: 2.683

Review 9.  Ultrasound screening in pregnancy: advancing technology, soft markers for fetal chromosomal aberrations, and unacknowledged ethical dilemmas.

Authors:  Linn Getz; Anne Luise Kirkengen
Journal:  Soc Sci Med       Date:  2003-05       Impact factor: 4.634

10.  Some limits of informed consent.

Authors:  O O'Neill
Journal:  J Med Ethics       Date:  2003-02       Impact factor: 2.903

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  26 in total

1.  A new era in prenatal testing: are we prepared?

Authors:  Dagmar Schmitz
Journal:  Med Health Care Philos       Date:  2013-08

Review 2.  From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges.

Authors:  Diana W Bianchi
Journal:  Nat Med       Date:  2012-07-06       Impact factor: 53.440

3.  "Don't Want No Risk and Don't Want No Problems": Public Understandings of the Risks and Benefits of Non-Invasive Prenatal Testing in the United States.

Authors:  Megan Allyse; Lauren Carter Sayres; Taylor Goodspeed; Marsha Michie; Mildred K Cho
Journal:  AJOB Empir Bioeth       Date:  2015

4.  Cell-free fetal DNA testing for fetal aneuploidy and beyond: clinical integration challenges in the US context.

Authors:  Megan Allyse; Lauren C Sayres; Jaime S King; Mary E Norton; Mildred K Cho
Journal:  Hum Reprod       Date:  2012-08-03       Impact factor: 6.918

Review 5.  Measuring informed choice in population-based reproductive genetic screening: a systematic review.

Authors:  Alice Grace Ames; Sylvia Ann Metcalfe; Alison Dalton Archibald; Rony Emily Duncan; Jon Emery
Journal:  Eur J Hum Genet       Date:  2014-05-21       Impact factor: 4.246

6.  Non-invasive prenatal testing: UK genetic counselors' experiences and perspectives.

Authors:  Elizabeth Alexander; Susan Kelly; Lauren Kerzin-Storrar
Journal:  J Genet Couns       Date:  2014-10-15       Impact factor: 2.537

7.  Noninvasive prenatal diagnosis: pregnant women's interest and expected uptake.

Authors:  Reana Tischler; Louanne Hudgins; Yair J Blumenfeld; Henry T Greely; Kelly E Ormond
Journal:  Prenat Diagn       Date:  2011-10-26       Impact factor: 3.050

8.  Best ethical practices for clinicians and laboratories in the provision of noninvasive prenatal testing.

Authors:  M A Allyse; L C Sayres; M Havard; J S King; H T Greely; L Hudgins; J Taylor; M E Norton; M K Cho; D Magnus; K E Ormond
Journal:  Prenat Diagn       Date:  2013-05-21       Impact factor: 3.050

9.  What women want: lead considerations for current and future applications of noninvasive prenatal testing in prenatal care.

Authors:  Ruth M Farrell; Patricia K Agatisa; Benjamin Nutter
Journal:  Birth       Date:  2014-05-14       Impact factor: 3.689

10.  Non-invasive prenatal testing for single gene disorders: exploring the ethics.

Authors:  Zuzana Deans; Melissa Hill; Lyn S Chitty; Celine Lewis
Journal:  Eur J Hum Genet       Date:  2012-11-28       Impact factor: 4.246

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