Literature DB >> 20121095

Natural products version 2.0: connecting genes to molecules.

Christopher T Walsh1, Michael A Fischbach.   

Abstract

Natural products have played a prominent role in the history of organic chemistry, and they continue to be important as drugs, biological probes, and targets of study for synthetic and analytical chemists. In this Perspective, we explore how connecting Nature's small molecules to the genes that encode them has sparked a renaissance in natural product research, focusing primarily on the biosynthesis of polyketides and non-ribosomal peptides. We survey monomer biogenesis, coupling chemistries from templated and non-templated pathways, and the broad set of tailoring reactions and hybrid pathways that give rise to the diverse scaffolds and functionalization patterns of natural products. We conclude by considering two questions: What would it take to find all natural product scaffolds? What kind of scientists will be studying natural products in the future?

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Year:  2010        PMID： 20121095      PMCID： PMC2828520          DOI： 10.1021/ja909118a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  302 in total

1.  Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.).

Authors:  Philip A. S. Lowden; Barrie Wilkinson; Günter A. Böhm; Sandeep Handa; Heinz G. Floss; Peter F. Leadlay; James Staunton
Journal:  Angew Chem Int Ed Engl       Date:  2001-02-16       Impact factor: 15.336

Review 2.  Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

Authors:  Elizabeth S Sattely; Michael A Fischbach; Christopher T Walsh
Journal:  Nat Prod Rep       Date:  2008-05-23       Impact factor: 13.423

3.  Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.

Authors:  Zheng You; Satoshi Omura; Haruo Ikeda; David E Cane
Journal:  Arch Biochem Biophys       Date:  2006-11-22       Impact factor: 4.013

Review 4.  Chemical biology of tetracycline antibiotics.

Authors:  Bijan Zakeri; Gerard D Wright
Journal:  Biochem Cell Biol       Date:  2008-04       Impact factor: 3.626

5.  Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity.

Authors:  Wendy L Kelly; Nathan J Hillson; Christopher T Walsh
Journal:  Biochemistry       Date:  2005-10-11       Impact factor: 3.162

6.  Evolution of sensory complexity recorded in a myxobacterial genome.

Authors:  B S Goldman; W C Nierman; D Kaiser; S C Slater; A S Durkin; J A Eisen; J Eisen; C M Ronning; W B Barbazuk; M Blanchard; C Field; C Halling; G Hinkle; O Iartchuk; H S Kim; C Mackenzie; R Madupu; N Miller; A Shvartsbeyn; S A Sullivan; M Vaudin; R Wiegand; H B Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-02       Impact factor: 11.205

7.  The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Authors:  Wen Liu; Koichi Nonaka; Liping Nie; Jian Zhang; Steven D Christenson; Juyun Bae; Steven G Van Lanen; Emmanuel Zazopoulos; Chris M Farnet; Catherine F Yang; Ben Shen
Journal:  Chem Biol       Date:  2005-03

8.  Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis.

Authors:  Olena Pylypenko; Francesca Vitali; Katja Zerbe; John A Robinson; Ilme Schlichting
Journal:  J Biol Chem       Date:  2003-07-29       Impact factor: 5.157

9.  Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin.

Authors:  Andrew W Schultz; Dong-Chan Oh; John R Carney; R Thomas Williamson; Daniel W Udwary; Paul R Jensen; Steven J Gould; William Fenical; Bradley S Moore
Journal:  J Am Chem Soc       Date:  2008-03-11       Impact factor: 15.419

10.  Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.

Authors:  R H Lambalot; D E Cane; J J Aparicio; L Katz
Journal:  Biochemistry       Date:  1995-02-14       Impact factor: 3.162
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  137 in total

1.  Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.

Authors:  Wayne K W Chou; Immacolata Fanizza; Takuma Uchiyama; Mamoru Komatsu; Haruo Ikeda; David E Cane
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

2.  Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.

Authors:  Yunfeng Hu; Wayne K W Chou; Russell Hopson; David E Cane
Journal:  Chem Biol       Date:  2011-01-28

Review 3.  Computational tools for the synthetic design of biochemical pathways.

Authors:  Marnix H Medema; Renske van Raaphorst; Eriko Takano; Rainer Breitling
Journal:  Nat Rev Microbiol       Date:  2012-01-23       Impact factor: 60.633

4.  Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.

Authors:  Aram Chang; Shanteri Singh; Kate E Helmich; Randal D Goff; Craig A Bingman; Jon S Thorson; George N Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-10       Impact factor: 11.205

5.  A massively spectacular view of the chemical lives of microbes.

Authors:  Matthew F Traxler; Roberto Kolter
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

6.  Catalysis at the intersection of biology, chemistry, and medicine.

Authors:  Christopher T Walsh
Journal:  J Biol Chem       Date:  2010-07-01       Impact factor: 5.157

Review 7.  Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms.

Authors:  Marnix H Medema; Rainer Breitling; Roel Bovenberg; Eriko Takano
Journal:  Nat Rev Microbiol       Date:  2010-12-29       Impact factor: 60.633

Review 8.  Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.

Authors:  Heather L Condurso; Steven D Bruner
Journal:  Nat Prod Rep       Date:  2012-06-25       Impact factor: 13.423

Review 9.  Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2015-09-12       Impact factor: 3.346

10.  Response of Secondary Metabolism of Hypogean Actinobacterial Genera to Chemical and Biological Stimuli.

Authors:  Brett C Covington; Jeffrey M Spraggins; Audrey E Ynigez-Gutierrez; Zachary B Hylton; Brian O Bachmann
Journal:  Appl Environ Microbiol       Date:  2018-09-17       Impact factor: 4.792
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