Literature DB >> 11241621

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.).

Philip A. S. Lowden1, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton.   

Abstract

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Year:  2001        PMID： 11241621

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  6 in total

1.  Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

Authors:  SangJoon Mo; Dong Hwan Kim; Jong Hyun Lee; Je Won Park; Devi B Basnet; Yeon Hee Ban; Young Ji Yoo; Shu-wei Chen; Sung Ryeol Park; Eun Ae Choi; Eunji Kim; Ying-Yu Jin; Sung-Kwon Lee; Ju Yeol Park; Yuan Liu; Mi Ok Lee; Keum Soon Lee; Sang Jun Kim; Dooil Kim; Byoung Chul Park; Sang-gi Lee; Ho Jeong Kwon; Joo-Won Suh; Bradley S Moore; Si-Kyu Lim; Yeo Joon Yoon
Journal:  J Am Chem Soc       Date:  2010-12-22       Impact factor: 15.419

Review 2.  Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.

Authors:  Mohini Ghatge; Nadaraj Palaniappan; Suparna Das Choudhuri; Kevin Reynolds
Journal:  J Ind Microbiol Biotechnol       Date:  2006-04-12       Impact factor: 3.346

3.  Origin of the allyl group in FK506 biosynthesis.

Authors:  Dusan Goranovic; Gregor Kosec; Peter Mrak; Stefan Fujs; Jaka Horvat; Enej Kuscer; Gregor Kopitar; Hrvoje Petkovic
Journal:  J Biol Chem       Date:  2010-03-01       Impact factor: 5.157

4.  Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Authors:  Jennifer N Andexer; Steven G Kendrew; Mohammad Nur-e-Alam; Orestis Lazos; Teresa A Foster; Anna-Sophie Zimmermann; Tony D Warneck; Dipen Suthar; Nigel J Coates; Frank E Koehn; Jerauld S Skotnicki; Guy T Carter; Matthew A Gregory; Christine J Martin; Steven J Moss; Peter F Leadlay; Barrie Wilkinson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

5.  Natural products version 2.0: connecting genes to molecules.

Authors:  Christopher T Walsh; Michael A Fischbach
Journal:  J Am Chem Soc       Date:  2010-03-03       Impact factor: 15.419

6.  Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases.

Authors:  Yi Tang; Taek Soon Lee; Chaitan Khosla
Journal:  PLoS Biol       Date:  2004-02-17       Impact factor: 8.029
  6 in total

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