Literature DB >> 18663394

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

Elizabeth S Sattely1, Michael A Fischbach, Christopher T Walsh.   

Abstract

This review surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates; 344 references are cited.

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Year:  2008        PMID： 18663394     DOI： 10.1039/b801747f

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  64 in total

1.  Catalysis at the intersection of biology, chemistry, and medicine.

Authors:  Christopher T Walsh
Journal:  J Biol Chem       Date:  2010-07-01       Impact factor: 5.157

2.  A novel docking domain interface model predicting recombination between homoeologous modular biosynthetic gene clusters.

Authors:  Antonio Starcevic; Janko Diminic; Jurica Zucko; Mouhsine Elbekali; Tobias Schlosser; Mohamed Lisfi; Ana Vukelic; Paul F Long; Daslav Hranueli; John Cullum
Journal:  J Ind Microbiol Biotechnol       Date:  2010-11-24       Impact factor: 3.346

Review 3.  Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms.

Authors:  Marnix H Medema; Rainer Breitling; Roel Bovenberg; Eriko Takano
Journal:  Nat Rev Microbiol       Date:  2010-12-29       Impact factor: 60.633

Review 4.  Total (bio)synthesis: strategies of nature and of chemists.

Authors:  Alexandra A Roberts; Katherine S Ryan; Bradley S Moore; Tobias A M Gulder
Journal:  Top Curr Chem       Date:  2010

Review 5.  How nature morphs peptide scaffolds into antibiotics.

Authors:  Elizabeth M Nolan; Christopher T Walsh
Journal:  Chembiochem       Date:  2009-01-05       Impact factor: 3.164

Review 6.  Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.

Authors:  Christopher T Walsh; Robert V O'Brien; Chaitan Khosla
Journal:  Angew Chem Int Ed Engl       Date:  2013-05-31       Impact factor: 15.336

7.  Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.

Authors:  Bo Li; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

Review 8.  Biosynthesis of aromatic polyketides in bacteria.

Authors:  Abhirup Das; Chaitan Khosla
Journal:  Acc Chem Res       Date:  2009-05-19       Impact factor: 22.384

9.  Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.

Authors:  Eric J Drake; Andrew M Gulick
Journal:  J Mol Biol       Date:  2008-09-19       Impact factor: 5.469

10.  In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides.

Authors:  John A Kalaitzis; Qian Cheng; Paul M Thomas; Neil L Kelleher; Bradley S Moore
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050
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