Literature DB >> 19936266

Pd/C-mediated synthesis of indoles in water.

Mohosin Layek1, Udaya Lakshmi, Dipak Kalita, Deepak Kumar Barange, Aminul Islam, K Mukkanti, Manojit Pal.   

Abstract

We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.

Entities:  

Keywords:  C–C bond; charcoal; copper; indoles; palladium

Year:  2009        PMID： 19936266      PMCID： PMC2779661          DOI： 10.3762/bjoc.5.46

Source DB:  PubMed          Journal:  Beilstein J Org Chem        ISSN： 1860-5397            Impact factor:   2.883


  11 in total

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7.  Novel, selective indole-based ECE inhibitors: lead optimization via solid-phase and classical synthesis.

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8.  3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.

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9.  Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability.

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10.  Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

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  5 in total

1.  Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates.

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Review 3.  Recent advances in the synthesis of N-containing heteroaromatics via heterogeneously transition metal catalysed cross-coupling reactions.

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Journal:  RSC Adv       Date:  2020-01-02       Impact factor: 4.036

5.  Palladium-catalyzed C-N and C-O bond formation of N-substituted 4-bromo-7-azaindoles with amides, amines, amino acid esters and phenols.

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  5 in total

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