| Literature DB >> 16455251 |
Aleksandr Kolesnikov1, Roopa Rai, Wendy B Young, Joyce Mordenti, Liang Liu, Steven Torkelson, William D Shrader, Ellen M Leahy, Huiyong Hu, Erik Gjerstad, James Janc, Bradley A Katz, Paul A Sprengeler.
Abstract
Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.Mesh：
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Year: 2006 PMID： 16455251 DOI： 10.1016/j.bmcl.2006.01.037
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823