| Literature DB >> 16621546 |
Yuichi Sugimoto1, Atsushi Shimizu, Tetsuya Kato, Atsushi Satoh, Satoshi Ozaki, Hisashi Ohta, Osamu Okamoto.
Abstract
A novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered. Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure-activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound.Entities:
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Year: 2006 PMID： 16621546 DOI： 10.1016/j.bmcl.2006.03.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823