Literature DB >> 15624920

A concise synthesis of a novel antiangiogenic tyrosine kinase inhibitor.

Joseph F Payack1, Enrique Vazquez, Louis Matty, Michael H Kress, James McNamara.   

Abstract

An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indole boronation and a dicyclohexylamine-mediated Suzuki coupling.

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Year:  2005        PMID： 15624920     DOI： 10.1021/jo048334k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Pd/C-mediated synthesis of indoles in water.

Authors:  Mohosin Layek; Udaya Lakshmi; Dipak Kalita; Deepak Kumar Barange; Aminul Islam; K Mukkanti; Manojit Pal
Journal:  Beilstein J Org Chem       Date:  2009-09-23       Impact factor: 2.883

2.  A facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles.

Authors:  Mikaël Brasse; Jonathan A Ellman; Robert G Bergman
Journal:  Chem Commun (Camb)       Date:  2011-03-29       Impact factor: 6.222

3.  Palladium-catalyzed cross-coupling of five-membered heterocyclic silanolates.

Authors:  Scott E Denmark; John D Baird; Christopher S Regens
Journal:  J Org Chem       Date:  2008-01-19       Impact factor: 4.354

4.  Scope of the Suzuki-Miyaura cross-coupling reactions of potassium heteroaryltrifluoroborates.

Authors:  Gary A Molander; Belgin Canturk; Lauren E Kennedy
Journal:  J Org Chem       Date:  2009-02-06       Impact factor: 4.354
  4 in total

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