| Literature DB >> 16085415 |
Michael Brands1, Jens-Kerim Ergüden, Kentaro Hashimoto, Dirk Heimbach, Christian Schröder, Stephan Siegel, Johannes-Peter Stasch, Stefan Weigand.
Abstract
A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. We report systematic optimization of this compound class by means of classical and solid-phase chemistry. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE.Entities:
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Year: 2005 PMID： 16085415 DOI： 10.1016/j.bmcl.2005.06.085
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823