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Literature DB >> 19903474

Distinct genetic code expansion strategies for selenocysteine and pyrrolysine are reflected in different aminoacyl-tRNA formation systems.

Jing Yuan¹, Patrick O'Donoghue, Alex Ambrogelly, Sarath Gundllapalli, R Lynn Sherrer, Sotiria Palioura, Miljan Simonović, Dieter Söll.

Abstract

Selenocysteine and pyrrolysine, known as the 21st and 22nd amino acids, are directly inserted into growing polypeptides during translation. Selenocysteine is synthesized via a tRNA-dependent pathway and decodes UGA (opal) codons. The incorporation of selenocysteine requires the concerted action of specific RNA and protein elements. In contrast, pyrrolysine is ligated directly to tRNA(Pyl) and inserted into proteins in response to UAG (amber) codons without the need for complex re-coding machinery. Here we review the latest updates on the structure and mechanisms of molecules involved in Sec-tRNA(Sec) and Pyl-tRNA(Pyl) formation as well as the distribution of the Pyl-decoding trait.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2010 PMID： 19903474 PMCID： PMC2795046 DOI： 10.1016/j.febslet.2009.11.005

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

64 in total

1. Gene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine.

Authors: W Leinfelder; E Zehelein; M A Mandrand-Berthelot; A Böck
Journal: Nature Date: 1988-02-25 Impact factor: 49.962

2. The unusually long amino acid acceptor stem of Escherichia coli selenocysteine tRNA results from abnormal cleavage by RNase P.

Authors: U Burkard; D Söll
Journal: Nucleic Acids Res Date: 1988-12-23 Impact factor: 16.971

Review 3. Pathogenicity islands and the evolution of microbes.

Authors: J Hacker; J B Kaper
Journal: Annu Rev Microbiol Date: 2000 Impact factor: 15.500

4. Selenoprotein synthesis in E. coli. Purification and characterisation of the enzyme catalysing selenium activation.

Authors: A Ehrenreich; K Forchhammer; P Tormay; B Veprek; A Böck
Journal: Eur J Biochem Date: 1992-06-15

5. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.

Authors: Bradley A Carlson; Xue-Ming Xu; Gregory V Kryukov; Mahadev Rao; Marla J Berry; Vadim N Gladyshev; Dolph L Hatfield
Journal: Proc Natl Acad Sci U S A Date: 2004-08-18 Impact factor: 11.205

6. The transamidosome: a dynamic ribonucleoprotein particle dedicated to prokaryotic tRNA-dependent asparagine biosynthesis.

Authors: Marc Bailly; Mickaël Blaise; Bernard Lorber; Hubert Dominique Becker; Daniel Kern
Journal: Mol Cell Date: 2007-10-26 Impact factor: 17.970

Review 7. The many levels of control on bacterial selenoprotein synthesis.

Authors: Satoko Yoshizawa; August Böck
Journal: Biochim Biophys Acta Date: 2009-03-27

8. Structure of a tRNA-dependent kinase essential for selenocysteine decoding.

Authors: Yuhei Araiso; R Lynn Sherrer; Ryuichiro Ishitani; Joanne M L Ho; Dieter Söll; Osamu Nureki
Journal: Proc Natl Acad Sci U S A Date: 2009-09-10 Impact factor: 11.205

9. UAG readthrough during TMV RNA translation: isolation and sequence of two tRNAs with suppressor activity from tobacco plants.

Authors: H Beier; M Barciszewska; G Krupp; R Mitnacht; H J Gross
Journal: EMBO J Date: 1984-02 Impact factor: 11.598

10. The length and the secondary structure of the D-stem of human selenocysteine tRNA are the major identity determinants for serine phosphorylation.

Authors: X Q Wu; H J Gross
Journal: EMBO J Date: 1994-01-01 Impact factor: 11.598

26 in total

Distinct genetic code expansion strategies for selenocysteine and pyrrolysine are reflected in different aminoacyl-tRNA formation systems.

1. Gene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine.

2. The unusually long amino acid acceptor stem of Escherichia coli selenocysteine tRNA results from abnormal cleavage by RNase P.

Review 3. Pathogenicity islands and the evolution of microbes.

4. Selenoprotein synthesis in E. coli. Purification and characterisation of the enzyme catalysing selenium activation.

5. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.

6. The transamidosome: a dynamic ribonucleoprotein particle dedicated to prokaryotic tRNA-dependent asparagine biosynthesis.

Review 7. The many levels of control on bacterial selenoprotein synthesis.

8. Structure of a tRNA-dependent kinase essential for selenocysteine decoding.

9. UAG readthrough during TMV RNA translation: isolation and sequence of two tRNAs with suppressor activity from tobacco plants.

10. The length and the secondary structure of the D-stem of human selenocysteine tRNA are the major identity determinants for serine phosphorylation.

1. Pyrrolysyl-tRNA synthetase variants reveal ancestral aminoacylation function.

2. Evolution of the genetic code by incorporation of amino acids that improved or changed protein function.

3. UGA is an additional glycine codon in uncultured SR1 bacteria from the human microbiota.

4. Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.

5. Evolving tRNA(Sec) for efficient canonical incorporation of selenocysteine.

6. A tRNA-dependent cysteine biosynthesis enzyme recognizes the selenocysteine-specific tRNA in Escherichia coli.

7. Human tRNA(Sec) associates with HeLa membranes, cell lipid liposomes, and synthetic lipid bilayers.

Review 8. Selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea.

9. Recoding the genetic code with selenocysteine.

Review 10. Genetic code flexibility in microorganisms: novel mechanisms and impact on physiology.