Literature DB >> 12414779

Use of a single monoclonal antibody to determine the susceptibilities of herpes simplex virus type 1 and type 2 clinical isolates to acyclovir.

Christine Chutkowski1, Betty Olson, Ann McDonough, James Mahoney, James J McSharry.   

Abstract

This report describes a flow cytometry drug susceptibility assay that uses a single fluorochrome-labeled monoclonal antibody to determine the acyclovir susceptibilities of herpes simplex virus (HSV) type 1 or type 2 clinical isolates. This assay yields 50% effective doses (drug concentrations that reduce the number of antigen-positive cells by 50%) for HSV clinical isolates that are equivalent to those obtained with the plaque reduction assay.

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Year:  2002        PMID： 12414779      PMCID： PMC130122          DOI： 10.1128/cdli.9.6.1379-1381.2002

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  25 in total

1.  Improved DNA hybridization method for detection of acyclovir-resistant herpes simplex virus.

Authors:  E M Swierkosz; D R Scholl; J L Brown; J D Jollick; C A Gleaves
Journal:  Antimicrob Agents Chemother       Date:  1987-10       Impact factor: 5.191

2.  Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.

Authors:  P Tebas; E C Stabell; P D Olivo
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

3.  Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient.

Authors:  R G Kost; E L Hill; M Tigges; S E Straus
Journal:  N Engl J Med       Date:  1993-12-09       Impact factor: 91.245

Review 4.  "The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.

Authors:  A K Field; K K Biron
Journal:  Clin Microbiol Rev       Date:  1994-01       Impact factor: 26.132

5.  Correlation between response to acyclovir and foscarnet therapy and in vitro susceptibility result for isolates of herpes simplex virus from human immunodeficiency virus-infected patients.

Authors:  S Safrin; T Elbeik; L Phan; D Robinson; J Rush; A Elbaggari; J Mills
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191

6.  A rapid screen test for in vitro susceptibility of clinical herpes simplex virus isolates.

Authors:  S Safrin; T Elbeik; J Mills
Journal:  J Infect Dis       Date:  1994-04       Impact factor: 5.226

Review 7.  New therapeutic approaches to the alphaherpesvirus infections.

Authors:  K A Cassady; R J Whitley
Journal:  J Antimicrob Chemother       Date:  1997-02       Impact factor: 5.790

8.  Rapid detection of herpes simplex virus in clinical samples by flow cytometry after amplification in tissue culture.

Authors:  J J McSharry; R Costantino; M B McSharry; R A Venezia; J M Lehman
Journal:  J Clin Microbiol       Date:  1990-08       Impact factor: 5.948

9.  Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child.

Authors:  C D Sibrack; L T Gutman; C M Wilfert; C McLaren; M H St Clair; P M Keller; D W Barry
Journal:  J Infect Dis       Date:  1982-11       Impact factor: 5.226

10.  Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance.

Authors:  G Darby; H J Field; S A Salisbury
Journal:  Nature       Date:  1981-01-01       Impact factor: 49.962
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  2 in total

1.  Phenotypic drug susceptibility assay for influenza virus neuraminidase inhibitors.

Authors:  James J McSharry; Ann C McDonough; Betty A Olson; George L Drusano
Journal:  Clin Diagn Lab Immunol       Date:  2004-01

2.  Antiviral activities of extracts from Hong Kong seaweeds.

Authors:  Hui Wang; Engchoon Vincent Ooi; Put O Ang
Journal:  J Zhejiang Univ Sci B       Date:  2008-12       Impact factor: 3.066
  2 in total

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