Literature DB >> 169388

DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.

G M Aron, D J Purifoy, P A Schaffer.   

Abstract

Fifteen temperature-sensitive mutants of herpes simplex virus type 1 were studied with regard to the relationship between their ability to synthesize viral DNA and to induce viral DNA polymerase (DP) activity at permissive (34 C) and nonpermissive (39 C) temperatures. At 34 C, all mutants synthesized viral DNA, while at 39 C four mutants demonstrated a DNA+ phenotype, three were DNA+/-, and eight were DNA-. DNA+ mutants induced levels of DP activity similar to thhose of the wild-type virus at both temperatures, and DNA+/- mutants induced reduced levels of DP activity at 39 C but not at 34 C. Among the DNA- mutants three were DP+, two were DP+/-, and three showed reduced DP activity at 34 C with no DP activity at 39 C. DNA-, DP- mutants induced the synthesis of a temperature-sensitive DP as determined by in vivo studies.

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Year:  1975        PMID： 169388      PMCID： PMC354696     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

1.  Acquisition of thymidine kinase activity by herpes simplex-infected mouse fibroblast cells.

Authors:  S KIT; D R DUBBS
Journal:  Biochem Biophys Res Commun       Date:  1963-04-02       Impact factor: 3.575

2.  The synthesis and fate of pseudorabies virus DNA in infected mammalian cells in the stationary phase of growth.

Authors:  T BEN-PORAT; A S KAPLAN
Journal:  Virology       Date:  1963-06       Impact factor: 3.616

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Activation of a defective DNA polymerase in a temperature-sensitive mutant of bacteriophage T4.

Authors:  M N Swartz; H Nakamura; I R Lehman
Journal:  Virology       Date:  1972-02       Impact factor: 3.616

5.  Electron microscopic studies of temperature-sensitive mutants of herpes simplex virus type 1.

Authors:  P A Schaffer; J P Brunschwig; R M McCombs; M Benyesh-Melnick
Journal:  Virology       Date:  1974-12       Impact factor: 3.616

6.  A temperature-sensitive mutant of herpes simplex virus defective in glycoprotein synthesis.

Authors:  P A Schaffer; R J Courtney; R M McCombs; M Benyesh-Melnick
Journal:  Virology       Date:  1971-11       Impact factor: 3.616

7.  Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus.

Authors:  H M Keir; J Hay; J M Morrison; H Subak-Sharpe
Journal:  Nature       Date:  1966-04-23       Impact factor: 49.962

8.  Immunological evidence for a specific DNA polymerase produced after infection by herpes simplex virus.

Authors:  H M Keir; H Subak-Sharpe; W I Shedden; D H Watson; P Wildy
Journal:  Virology       Date:  1966-09       Impact factor: 3.616

9.  Reversible inactivation of T4 ts DNA polymerase mutants in vivo.

Authors:  J D Karam; J F Speyer
Journal:  Virology       Date:  1970-09       Impact factor: 3.616

10.  The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5.

Authors:  A De Waard; A V Paul; I R Lehman
Journal:  Proc Natl Acad Sci U S A       Date:  1965-10       Impact factor: 11.205
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  58 in total

1.  Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2.

Authors:  P A Schaffer; V C Carter; M C Timbury
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

2.  DNA-negative temperature-sensitive mutants of herpes simplex virus type 1: patterns of viral DNA synthesis after temperature shift-up.

Authors:  P A Schaffer; D R Bone; R J Courtney
Journal:  J Virol       Date:  1976-03       Impact factor: 5.103

3.  Contributions of herpes simplex virus 1 envelope proteins to entry by endocytosis.

Authors:  Tri Komala Sari; Suzanne M Pritchard; Cristina W Cunha; George A Wudiri; Elizabeth I Laws; Hector C Aguilar; Naomi S Taus; Anthony V Nicola
Journal:  J Virol       Date:  2013-10-09       Impact factor: 5.103

4.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

5.  2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent.

Authors:  C Lopez; K A Watanabe; J J Fox
Journal:  Antimicrob Agents Chemother       Date:  1980-05       Impact factor: 5.191

6.  Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.

Authors:  A I Marcy; P D Olivo; M D Challberg; D M Coen
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

7.  Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.

Authors:  A I Marcy; D R Yager; D M Coen
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

8.  Synthesis of viral and host DNA in isolated chromatin from herpes simplex virus-infected HeLa cells.

Authors:  M Yamada; G Brun; A Weissbach
Journal:  J Virol       Date:  1978-05       Impact factor: 5.103

9.  Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

Authors:  J S Gibbs; H C Chiou; K F Bastow; Y C Cheng; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

10.  Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus.

Authors:  C S Crumpacker; P N Kowalsky; S A Oliver; L E Schnipper; A K Field
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205
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