Literature DB >> 19535900

Effects of p21 deletion in mouse models of premature aging.

Erica K Benson1, Bo Zhao, David A Sassoon, Sam W Lee, Stuart A Aaronson.   

Abstract

An approach to investigate the role of cellular senescence in organismal aging has been to abrogate signaling pathways known to induce cellular senescence and to assess the effects in mouse models of premature aging. Recently, we reported the effect of loss of function of p21, a gene implicated in p53-induced cellular senescence, in the background of the Ku80(-/-) premature aging mouse (Zhao et al., EMBO Rep 2009). Here, we provide an overview of the effects of p21 deletion in different models of premature aging.

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Year:  2009        PMID： 19535900      PMCID： PMC5839167          DOI： 10.4161/cc.8.13.8997

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  58 in total

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Journal:  Cell       Date:  1999-05-14       Impact factor: 41.582

2.  Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

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Journal:  Nat Genet       Date:  2004-04-18       Impact factor: 38.330

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Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

4.  Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

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Journal:  Oncogene       Date:  2001-01-18       Impact factor: 9.867

Review 5.  Cellular senescence as a tumor-suppressor mechanism.

Authors:  J Campisi
Journal:  Trends Cell Biol       Date:  2001-11       Impact factor: 20.808

6.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-26       Impact factor: 11.205

Review 7.  Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Authors:  Judith Campisi
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

Review 8.  Aging and genome maintenance: lessons from the mouse?

Authors:  Paul Hasty; Judith Campisi; Jan Hoeijmakers; Harry van Steeg; Jan Vijg
Journal:  Science       Date:  2003-02-28       Impact factor: 47.728

9.  Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

Authors:  Y Xu; T Ashley; E E Brainerd; R T Bronson; M S Meyn; D Baltimore
Journal:  Genes Dev       Date:  1996-10-01       Impact factor: 11.361

10.  Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts.

Authors:  H Tahara; E Sato; A Noda; T Ide
Journal:  Oncogene       Date:  1995-03-02       Impact factor: 9.867
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  7 in total

1.  Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.

Authors:  Tatiana V Pospelova; Tatiana V Bykova; Svetlana G Zubova; Natalia V Katolikova; Natalia M Yartzeva; Valery A Pospelov
Journal:  Cell Cycle       Date:  2013-12-02       Impact factor: 4.534

Review 2.  Examination of the expanding pathways for the regulation of p21 expression and activity.

Authors:  Yong-Sam Jung; Yingjuan Qian; Xinbin Chen
Journal:  Cell Signal       Date:  2010-01-25       Impact factor: 4.315

3.  Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.

Authors:  Jackson R Taylor; Brian D Lehmann; William H Chappell; Stephen L Abrams; Linda S Steelman; James A McCubrey
Journal:  Oncotarget       Date:  2011-08

4.  Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.

Authors:  Abhishek Chandra; Anthony B Lagnado; Joshua N Farr; Madison Doolittle; Tamara Tchkonia; James L Kirkland; Nathan K LeBrasseur; Paul D Robbins; Laura J Niedernhofer; Yuji Ikeno; João F Passos; David G Monroe; Robert J Pignolo; Sundeep Khosla
Journal:  Aging Cell       Date:  2022-04-01       Impact factor: 11.005

5.  The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.

Authors:  Xiaoman Li; Hongde Xu; Chongan Xu; Meina Lin; Xiaoyu Song; Fei Yi; Yanling Feng; Kathleen A Coughlan; William Chi-Shing Cho; Sang Soo Kim; Liu Cao
Journal:  Int J Mol Sci       Date:  2013-01-25       Impact factor: 5.923

Review 6.  Role of p53 in the Regulation of Cellular Senescence.

Authors:  Mahmut Mijit; Valentina Caracciolo; Antonio Melillo; Fernanda Amicarelli; Antonio Giordano
Journal:  Biomolecules       Date:  2020-03-08

7.  TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.

Authors:  Petra Mlcochova; Helena Winstone; Lorena Zuliani-Alvarez; Ravindra K Gupta
Journal:  Cell Rep       Date:  2020-03-24       Impact factor: 9.423
  7 in total

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