| Literature DB >> 12610296 |
Paul Hasty1, Judith Campisi, Jan Hoeijmakers, Harry van Steeg, Jan Vijg.
Abstract
Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.Entities:
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Year: 2003 PMID： 12610296 DOI： 10.1126/science.1079161
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728