Literature DB >> 11684439

Cellular senescence as a tumor-suppressor mechanism.

J Campisi1.   

Abstract

Organisms with renewable tissues had to evolve mechanisms to prevent the development of cancer. One such mechanism is cellular senescence, which irreversibly arrests the growth of cells at risk for neoplastic transformation. Recent findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism.

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Year:  2001        PMID： 11684439     DOI： 10.1016/s0962-8924(01)02151-1

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  278 in total

Review 1.  Using mice to examine p53 functions in cancer, aging, and longevity.

Authors:  Lawrence A Donehower
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-11-04       Impact factor: 10.005

Review 2.  Bypassing cellular senescence by genetic screening tools.

Authors:  Mar Vergel; Amancio Carnero
Journal:  Clin Transl Oncol       Date:  2010-06       Impact factor: 3.405

3.  PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation.

Authors:  Hyo Jung Kim; Sun Ah Ham; Min Young Kim; Jung Seok Hwang; Hanna Lee; Eun Sil Kang; Taesik Yoo; Im Sun Woo; Chihiro Yabe-Nishimura; Kyung Shin Paek; Jin-Hoi Kim; Han Geuk Seo
Journal:  J Biol Chem       Date:  2011-11-09       Impact factor: 5.157

4.  Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.

Authors:  Dimitri Lodygin; Antje Menssen; Heiko Hermeking
Journal:  J Clin Invest       Date:  2002-12       Impact factor: 14.808

5.  Glucocorticoids suppress selected components of the senescence-associated secretory phenotype.

Authors:  Remi-Martin Laberge; Lili Zhou; Melissa R Sarantos; Francis Rodier; Adam Freund; Peter L J de Keizer; Su Liu; Marco Demaria; Yu-Sheng Cong; Pankaj Kapahi; Pierre-Yves Desprez; Robert E Hughes; Judith Campisi
Journal:  Aging Cell       Date:  2012-04-17       Impact factor: 9.304

6.  Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.

Authors:  Eric M Blalock; James W Geddes; Kuey Chu Chen; Nada M Porter; William R Markesbery; Philip W Landfield
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-09       Impact factor: 11.205

7.  Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

Authors:  Liu Cao; Wenmei Li; Sangsoo Kim; Steven G Brodie; Chu-Xia Deng
Journal:  Genes Dev       Date:  2003-01-15       Impact factor: 11.361

8.  Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells.

Authors:  Susan M Bailey; Mark A Brenneman; Edwin H Goodwin
Journal:  Nucleic Acids Res       Date:  2004-07-16       Impact factor: 16.971

9.  Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells.

Authors:  Jaejoon Won; Seungwoo Chang; Sangtaek Oh; Tae Kook Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-19       Impact factor: 11.205

10.  Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche.

Authors:  Krastan B Blagoev
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-14       Impact factor: 11.205
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