| Literature DB >> 15734682 |
David B Lombard1, Katrin F Chua, Raul Mostoslavsky, Sonia Franco, Monica Gostissa, Frederick W Alt.
Abstract
Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability, metabolism, and aging. We conclude with a general discussion of the role of mutant mice in aging research and avenues for future investigation.Entities:
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Year: 2005 PMID： 15734682 DOI： 10.1016/j.cell.2005.01.028
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582