Literature DB >> 19199646

A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.

José C Aponte1, Abraham J Vaisberg, Rosario Rojas, Michel Sauvain, Walter H Lewis, Gerardo Lamas, César Sarasara, Robert H Gilman, Gerald B Hammond.   

Abstract

A multidisciplinary and international team of scientists was assembled in the early 1990s to conduct an ethnobotanical study of plants used by the Aguaruna people of the Peruvian Amazon forest. The initial ethnobotanical project, carried out under the auspices of an International Cooperative Biodiversity Grant (ICBG), led to the collection of approximately 4000 plant species. Some members of the original team of scientists have continued this collaboration by focusing on potential sources of new anticancer, anti-infective, and wound-healing agents. This effort has uncovered several secondary metabolites representing a wide variety of chemical diversity. In this short review we describe some bioactive compounds of interest as part of our continuing collaboration.

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Year:  2009        PMID: 19199646      PMCID: PMC5495650          DOI: 10.1021/np800630k

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  20 in total

Review 1.  The evolving role of natural products in drug discovery.

Authors:  Frank E Koehn; Guy T Carter
Journal:  Nat Rev Drug Discov       Date:  2005-03       Impact factor: 84.694

Review 2.  Drug discovery from medicinal plants.

Authors:  Marcy J Balunas; A Douglas Kinghorn
Journal:  Life Sci       Date:  2005-09-29       Impact factor: 5.037

Review 3.  Some thoughts on the future of ethnopharmacology.

Authors:  Geoffrey A Cordell; Michael D Colvard
Journal:  J Ethnopharmacol       Date:  2005-08-22       Impact factor: 4.360

4.  In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa.

Authors:  Gustavo Moura-Letts; León F Villegas; Ana Marçalo; Abraham J Vaisberg; Gerald B Hammond
Journal:  J Nat Prod       Date:  2006-06       Impact factor: 4.050

5.  Tree species richness of upper Amazonian forests.

Authors:  A H Gentry
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

6.  Chemistry. The renaissance of natural products as drug candidates.

Authors:  Ian Paterson; Edward A Anderson
Journal:  Science       Date:  2005-10-21       Impact factor: 47.728

7.  Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera.

Authors:  Rosario Rojas; Luz Caviedes; José C Aponte; Abraham J Vaisberg; Walter H Lewis; Gerardo Lamas; César Sarasara; Robert H Gilman; Gerald B Hammond
Journal:  J Nat Prod       Date:  2006-05       Impact factor: 4.050

8.  Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa.

Authors:  C C Neto; A J Vaisberg; B N Zhou; D G Kingston; G B Hammond
Journal:  Planta Med       Date:  2000-06       Impact factor: 3.352

9.  A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba.

Authors:  C A Wood; K Lee; A J Vaisberg; D G Kingston; C C Neto; G B Hammond
Journal:  Chem Pharm Bull (Tokyo)       Date:  2001-11       Impact factor: 1.645

10.  (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids.

Authors:  L F Villegas; A Marçalo; J Martin; I D Fernández; H Maldonado; A J Vaisberg; G B Hammond
Journal:  J Nat Prod       Date:  2001-10       Impact factor: 4.050

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  3 in total

1.  Ethnochemistry and human rights.

Authors:  Inna Abramova; Alexander Greer
Journal:  Chem Biodivers       Date:  2013-09       Impact factor: 2.408

Review 2.  Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.

Authors:  Hugo Cerecetto; Mercedes González
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-25

3.  Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death.

Authors:  Nicole S Stivers; Ashraful Islam; Elsa M Reyes-Reyes; Lavona K Casson; José C Aponte; Abraham J Vaisberg; Gerald B Hammond; Paula J Bates
Journal:  Molecules       Date:  2018-06-12       Impact factor: 4.411

  3 in total

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