Literature DB >> 16724857

Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera.

Rosario Rojas1, Luz Caviedes, José C Aponte, Abraham J Vaisberg, Walter H Lewis, Gerardo Lamas, César Sarasara, Robert H Gilman, Gerald B Hammond.   

Abstract

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 microg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

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Year:  2006        PMID： 16724857      PMCID： PMC5507661          DOI： 10.1021/np050554l

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  26 in total

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