Literature DB >> 10909276

Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa.

C C Neto, A J Vaisberg, B N Zhou, D G Kingston, G B Hammond.   

Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.

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Year:  2000        PMID： 10909276     DOI： 10.1055/s-2000-8583

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  5 in total

Review 1.  A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.

Authors:  José C Aponte; Abraham J Vaisberg; Rosario Rojas; Michel Sauvain; Walter H Lewis; Gerardo Lamas; César Sarasara; Robert H Gilman; Gerald B Hammond
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

Review 2.  Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.

Authors:  Anupam Bishayee; Shamima Ahmed; Nikoleta Brankov; Marjorie Perloff
Journal:  Front Biosci (Landmark Ed)       Date:  2011-01-01

3.  Organotypic culture of breast tumor explants as a multicellular system for the screening of natural compounds with antineoplastic potential.

Authors:  Irma Edith Carranza-Torres; Nancy Elena Guzmán-Delgado; Consuelo Coronado-Martínez; José Inocente Bañuelos-García; Ezequiel Viveros-Valdez; Javier Morán-Martínez; Pilar Carranza-Rosales
Journal:  Biomed Res Int       Date:  2015-05-17       Impact factor: 3.411

4.  Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera.

Authors:  Hoai Thi Nguyen; Duc Viet Ho; Hung Quoc Vo; Anh Tuan Le; Hien Minh Nguyen; Takeshi Kodama; Takuya Ito; Hiroyuki Morita; Ain Raal
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503

Review 5.  Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites.

Authors:  Seong-Ah Shin; Sun Young Moon; Woe-Yeon Kim; Seung-Mann Paek; Hyun Ho Park; Chang Sup Lee
Journal:  Int J Mol Sci       Date:  2018-09-06       Impact factor: 5.923
  5 in total

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