Literature DB >> 19188070

Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.

Marcus V N de Souza1, Karla C Pais, Carlos R Kaiser, Mônica A Peralta, Marcelle de L Ferreira, Maria C S Lourenço.   

Abstract

A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 microg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.

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Year:  2009        PMID： 19188070     DOI： 10.1016/j.bmc.2009.01.013

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

1.  Facilely accessible quinoline derivatives as potent antibacterial agents.

Authors:  Peng Teng; Chunhui Li; Zhong Peng; Vanderschouw Anne Marie; Alekhya Nimmagadda; Ma Su; Yaqiong Li; Xingmin Sun; Jianfeng Cai
Journal:  Bioorg Med Chem       Date:  2018-05-22       Impact factor: 3.641

2.  An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1H-pyrazole), and β-diketone in aqueous medium.

Authors:  Zhansheng Wang; Hui Xu; Lirong Yan; Qingyang Li; Liangce Rong
Journal:  Mol Divers       Date:  2017-08-21       Impact factor: 2.943

3.  4-[(E)-2-(2-Chloro-benzyl-idene)hydrazin-1-yl]quinolin-1-ium chloride dihydrate.

Authors:  Edward R T Tiekink; Solange M S V Wardell; James L Wardell; Marcelle de Lima Ferreira; Marcus V N de Souza; Carlos R Kaiser
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-23

4.  Quinoline: A versatile heterocyclic.

Authors:  Akranth Marella; Om Prakash Tanwar; Rikta Saha; Mohammad Rahmat Ali; Sandeep Srivastava; Mymoona Akhter; Mohammad Shaquiquzzaman; Mohammad Mumtaz Alam
Journal:  Saudi Pharm J       Date:  2012-03-29       Impact factor: 4.330

5.  (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate.

Authors:  Raoni S B Gonçalves; Marcus V N de Souza; Solange M S V Wardell; James L Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30

6.  7-Chloro-4-[(E)-2-(2,5-dimeth-oxy-benzyl-idene)hydrazin-1-yl]quinoline.

Authors:  Marcus V N de Souza; Marcelle de Lima Ferreira; Solange M S V Wardell; Edward R T Tiekink; James L Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-31

7.  4-[(E)-2-(2,4-Dichloro-benzyl-idene)hydrazin-1-yl]quinolin-1-ium chloride monohydrate.

Authors:  Solange M S V Wardell; Edward R T Tiekink; James L Wardell; Marcelle de Lima Ferreira; Marcus V N de Souza
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-31

8.  7-Chloro-4-[(E)-2-(3,4,5-trimeth-oxy-benzyl-idene)hydrazin-1-yl]quinoline.

Authors:  Marcelle de Lima Ferreira; Marcus V N de Souza; Solange M S V Wardell; Edward R T Tiekink; James L Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-28

9.  Design and synthesis of novel antileishmanial compounds.

Authors:  Melanie Loedige
Journal:  Int J Med Chem       Date:  2015-01-21

10.  Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure-Activity Relationship (HQSAR) Modeling of Amino-Imino Tautomers.

Authors:  Marcelle L F Bispo; Camilo H S Lima; Laura N F Cardoso; André L P Candéa; Flávio A F M Bezerra; Maria C S Lourenço; Maria G M O Henriques; Ricardo B Alencastro; Carlos R Kaiser; Marcus V N Souza; Magaly G Albuquerque
Journal:  Pharmaceuticals (Basel)       Date:  2017-06-09
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