OBJECTIVE: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. METHOD: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. RESULTS: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/para-hippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. CONCLUSIONS: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.
OBJECTIVE: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. METHOD: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. RESULTS: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/para-hippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. CONCLUSIONS: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.
Authors: P M Thompson; T D Cannon; K L Narr; T van Erp; V P Poutanen; M Huttunen; J Lönnqvist; C G Standertskjöld-Nordenstam; J Kaprio; M Khaledy; R Dail; C I Zoumalan; A W Toga Journal: Nat Neurosci Date: 2001-12 Impact factor: 24.884
Authors: Haiying Meng; Shelley D Smith; Karl Hager; Matthew Held; Jonathan Liu; Richard K Olson; Bruce F Pennington; John C DeFries; Joel Gelernter; Thomas O'Reilly-Pol; Stefan Somlo; Pawel Skudlarski; Sally E Shaywitz; Bennett A Shaywitz; Karen Marchione; Yu Wang; Murugan Paramasivam; Joseph J LoTurco; Grier P Page; Jeffrey R Gruen Journal: Proc Natl Acad Sci U S A Date: 2005-11-08 Impact factor: 11.205
Authors: Manuel F Casanova; James D Christensen; Jay Giedd; Judith M Rumsey; David L Garver; Gregory C Postel Journal: J Child Neurol Date: 2005-10 Impact factor: 1.987
Authors: D Harold; S Paracchini; T Scerri; M Dennis; N Cope; G Hill; V Moskvina; J Walter; A J Richardson; M J Owen; J F Stein; E D Green; M C O'Donovan; J Williams; A P Monaco Journal: Mol Psychiatry Date: 2006-10-10 Impact factor: 15.992
Authors: Cecilia Marino; Paola Scifo; Pasquale A Della Rosa; Sara Mascheretti; Andrea Facoetti; Maria L Lorusso; Roberto Giorda; Monica Consonni; Andrea Falini; Massimo Molteni; Jeffrey R Gruen; Daniela Perani Journal: Cortex Date: 2014-05-09 Impact factor: 4.027
Authors: S M Hadi Hosseini; Jessica M Black; Teresa Soriano; Nicolle Bugescu; Rociel Martinez; Mira M Raman; Shelli R Kesler; Fumiko Hoeft Journal: Neuroimage Date: 2013-01-17 Impact factor: 6.556