| Literature DB >> 16278297 |
Haiying Meng1, Shelley D Smith, Karl Hager, Matthew Held, Jonathan Liu, Richard K Olson, Bruce F Pennington, John C DeFries, Joel Gelernter, Thomas O'Reilly-Pol, Stefan Somlo, Pawel Skudlarski, Sally E Shaywitz, Bennett A Shaywitz, Karen Marchione, Yu Wang, Murugan Paramasivam, Joseph J LoTurco, Grier P Page, Jeffrey R Gruen.
Abstract
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration. The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD.Entities:
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Year: 2005 PMID： 16278297 PMCID： PMC1278934 DOI： 10.1073/pnas.0508591102
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205