Literature DB >> 23229871

Meta-analysis of the association between DCDC2 polymorphisms and risk of dyslexia.

Rong Zhong1, Beifang Yang, Hui Tang, Li Zou, Ranran Song, Ling-Qiang Zhu, Xiaoping Miao.   

Abstract

Developmental dyslexia (DD) is a highly heritable neurological disorder that is prevalent in school-aged children. The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. However, the associations between DCDC2 genetic variations and dyslexia have yielded inconclusive results. Clarifying the effects of DCDC2 polymorphisms on dyslexia risk will advance not only elucidation of the role of DCDC2 in the brain development but also development of possible therapeutic approach for dyslexia. In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.

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Year:  2012        PMID： 23229871     DOI： 10.1007/s12035-012-8381-7

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  31 in total

1.  Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses.

Authors:  Karen E Deffenbacher; Judith B Kenyon; Denise M Hoover; Richard K Olson; Bruce F Pennington; John C DeFries; Shelley D Smith
Journal:  Hum Genet       Date:  2004-05-11       Impact factor: 4.132

2.  Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.

Authors:  Johannes Schumacher; Heidi Anthoni; Faten Dahdouh; Inke R König; Axel M Hillmer; Nadine Kluck; Malou Manthey; Ellen Plume; Andreas Warnke; Helmut Remschmidt; Jutta Hülsmann; Sven Cichon; Cecilia M Lindgren; Peter Propping; Marco Zucchelli; Andreas Ziegler; Myriam Peyrard-Janvid; Gerd Schulte-Körne; Markus M Nöthen; Juha Kere
Journal:  Am J Hum Genet       Date:  2005-11-17       Impact factor: 11.025

3.  Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.

Authors:  Natalie Cope; Denise Harold; Gary Hill; Valentina Moskvina; Jim Stevenson; Peter Holmans; Michael J Owen; Michael C O'Donovan; Julie Williams
Journal:  Am J Hum Genet       Date:  2005-02-16       Impact factor: 11.025

4.  Functional disruption in the organization of the brain for reading in dyslexia.

Authors:  S E Shaywitz; B A Shaywitz; K R Pugh; R K Fulbright; R T Constable; W E Mencl; D P Shankweiler; A M Liberman; P Skudlarski; J M Fletcher; L Katz; K E Marchione; C Lacadie; C Gatenby; J C Gore
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

5.  Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia.

Authors:  Zoran Brkanac; Nicola H Chapman; Mark M Matsushita; Lani Chun; Kathleen Nielsen; Elizabeth Cochrane; Virginia W Berninger; Ellen M Wijsman; Wendy H Raskind
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2007-06-05       Impact factor: 3.568

6.  A longitudinal investigation of reading outcomes in children with language impairments.

Authors:  Hugh W Catts; Marc E Fey; J Bruce Tomblin; Xuyang Zhang
Journal:  J Speech Lang Hear Res       Date:  2002-12       Impact factor: 2.297

7.  Doublecortin and a tale of two serines.

Authors:  Joseph LoTurco
Journal:  Neuron       Date:  2004-01-22       Impact factor: 17.173

8.  Developmental dyslexia: four consecutive patients with cortical anomalies.

Authors:  A M Galaburda; G F Sherman; G D Rosen; F Aboitiz; N Geschwind
Journal:  Ann Neurol       Date:  1985-08       Impact factor: 10.422

9.  Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.

Authors:  D Harold; S Paracchini; T Scerri; M Dennis; N Cope; G Hill; V Moskvina; J Walter; A J Richardson; M J Owen; J F Stein; E D Green; M C O'Donovan; J Williams; A P Monaco
Journal:  Mol Psychiatry       Date:  2006-10-10       Impact factor: 15.992

10.  Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample.

Authors:  Kerstin U Ludwig; Johannes Schumacher; Gerd Schulte-Körne; Inke R König; Andreas Warnke; Ellen Plume; Heidi Anthoni; Myriam Peyrard-Janvid; Haiying Meng; Andreas Ziegler; Helmut Remschmidt; Juha Kere; Jeffrey R Gruen; Bertram Müller-Myhsok; Markus M Nöthen; Per Hoffmann
Journal:  Psychiatr Genet       Date:  2008-12       Impact factor: 2.574
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  11 in total

1.  The Roles of Genes in the Neuronal Migration and Neurite Outgrowth Network in Developmental Dyslexia: Single- and Multiple-Risk Genetic Variants.

Authors:  Shanshan Shao; Rui Kong; Li Zou; Rong Zhong; Jiao Lou; Jie Zhou; Shengnan Guo; Jia Wang; Xiaohui Zhang; Jiajia Zhang; Ranran Song
Journal:  Mol Neurobiol       Date:  2015-07-17       Impact factor: 5.590

2.  The DCDC2/intron 2 deletion and white matter disorganization: focus on developmental dyslexia.

Authors:  Cecilia Marino; Paola Scifo; Pasquale A Della Rosa; Sara Mascheretti; Andrea Facoetti; Maria L Lorusso; Roberto Giorda; Monica Consonni; Andrea Falini; Massimo Molteni; Jeffrey R Gruen; Daniela Perani
Journal:  Cortex       Date:  2014-05-09       Impact factor: 4.027

3.  Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.

Authors:  Else Eising; Nazanin Mirza-Schreiber; Eveline L de Zeeuw; Carol A Wang; Dongnhu T Truong; Andrea G Allegrini; Chin Yang Shapland; Gu Zhu; Karen G Wigg; Margot L Gerritse; Barbara Molz; Gökberk Alagöz; Alessandro Gialluisi; Filippo Abbondanza; Kaili Rimfeld; Marjolein van Donkelaar; Zhijie Liao; Philip R Jansen; Till F M Andlauer; Timothy C Bates; Manon Bernard; Kirsten Blokland; Milene Bonte; Anders D Børglum; Thomas Bourgeron; Daniel Brandeis; Fabiola Ceroni; Valéria Csépe; Philip S Dale; Peter F de Jong; John C DeFries; Jean-François Démonet; Ditte Demontis; Yu Feng; Scott D Gordon; Sharon L Guger; Marianna E Hayiou-Thomas; Juan A Hernández-Cabrera; Jouke-Jan Hottenga; Charles Hulme; Juha Kere; Elizabeth N Kerr; Tanner Koomar; Karin Landerl; Gabriel T Leonard; Maureen W Lovett; Heikki Lyytinen; Nicholas G Martin; Angela Martinelli; Urs Maurer; Jacob J Michaelson; Kristina Moll; Anthony P Monaco; Angela T Morgan; Markus M Nöthen; Zdenka Pausova; Craig E Pennell; Bruce F Pennington; Kaitlyn M Price; Veera M Rajagopal; Franck Ramus; Louis Richer; Nuala H Simpson; Shelley D Smith; Margaret J Snowling; John Stein; Lisa J Strug; Joel B Talcott; Henning Tiemeier; Marc P van der Schroeff; Ellen Verhoef; Kate E Watkins; Margaret Wilkinson; Margaret J Wright; Cathy L Barr; Dorret I Boomsma; Manuel Carreiras; Marie-Christine J Franken; Jeffrey R Gruen; Michelle Luciano; Bertram Müller-Myhsok; Dianne F Newbury; Richard K Olson; Silvia Paracchini; Tomáš Paus; Robert Plomin; Sheena Reilly; Gerd Schulte-Körne; J Bruce Tomblin; Elsje van Bergen; Andrew J O Whitehouse; Erik G Willcutt; Beate St Pourcain; Clyde Francks; Simon E Fisher
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-23       Impact factor: 12.779

4.  The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex.

Authors:  Alicia Che; Matthew J Girgenti; Joseph LoTurco
Journal:  Biol Psychiatry       Date:  2013-10-04       Impact factor: 13.382

5.  The role of DCDC2 genetic variants and low socioeconomic status in vulnerability to attention problems.

Authors:  Valentina Riva; Cecilia Marino; Roberto Giorda; Massimo Molteni; Maria Nobile
Journal:  Eur Child Adolesc Psychiatry       Date:  2014-07-11       Impact factor: 4.785

Review 6.  Imaging-genetics in dyslexia: connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments.

Authors:  John D Eicher; Jeffrey R Gruen
Journal:  Mol Genet Metab       Date:  2013-07-17       Impact factor: 4.797

7.  Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.

Authors:  John D Eicher; Natalie R Powers; Laura L Miller; Kathryn L Mueller; Sara Mascheretti; Cecilia Marino; Erik G Willcutt; John C DeFries; Richard K Olson; Shelley D Smith; Bruce F Pennington; J Bruce Tomblin; Susan M Ring; Jeffrey R Gruen
Journal:  Hum Genet       Date:  2014-02-09       Impact factor: 4.132

Review 8.  Neurogenetics of developmental dyslexia: from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms.

Authors:  S Mascheretti; A De Luca; V Trezzi; D Peruzzo; A Nordio; C Marino; F Arrigoni
Journal:  Transl Psychiatry       Date:  2017-01-03       Impact factor: 6.222

9.  DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.

Authors:  Yun Chen; Hua Zhao; Yi-Xin Zhang; Peng-Xiang Zuo
Journal:  Neural Regen Res       Date:  2017-02       Impact factor: 5.135

10.  A genome-wide association study for reading and language abilities in two population cohorts.

Authors:  M Luciano; D M Evans; N K Hansell; S E Medland; G W Montgomery; N G Martin; M J Wright; T C Bates
Journal:  Genes Brain Behav       Date:  2013-06-20       Impact factor: 3.449
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