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Literature DB >> 19092835

Detecting shared pathogenesis from the shared genetics of immune-related diseases.

Alexandra Zhernakova¹, Cleo C van Diemen, Cisca Wijmenga.

Abstract

Recent genetic studies have revealed shared immunological mechanisms in several immune-related disorders that further our understanding of the development and concomitance of these diseases. Our Review focuses on these shared aspects, using the novel findings of recently performed genome-wide association studies and non-synonymous SNP scans as a starting point. We discuss how identifying new genes that are associated with more than one autoimmune or chronic inflammatory disorder could explain the genetic basis of the shared pathogenesis of immune-related diseases. This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases.

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 19092835 DOI： 10.1038/nrg2489

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

139 in total

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Journal: Gastroenterology Date: 2006-07 Impact factor: 22.682

3. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.

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Journal: Nat Genet Date: 2005-04-17 Impact factor: 38.330

4. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.

Authors: David L Boone; Emre E Turer; Eric G Lee; Regina-Celeste Ahmad; Matthew T Wheeler; Colleen Tsui; Paula Hurley; Marcia Chien; Sophia Chai; Osamu Hitotsumatsu; Elizabeth McNally; Cecile Pickart; Averil Ma
Journal: Nat Immunol Date: 2004-08-29 Impact factor: 25.606

5. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

Authors: Geoffrey Hom; Robert R Graham; Barmak Modrek; Kimberly E Taylor; Ward Ortmann; Sophie Garnier; Annette T Lee; Sharon A Chung; Ricardo C Ferreira; P V Krishna Pant; Dennis G Ballinger; Roman Kosoy; F Yesim Demirci; M Ilyas Kamboh; Amy H Kao; Chao Tian; Iva Gunnarsson; Anders A Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Susan Manzi; Michael F Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A Criswell; Peter K Gregersen; Timothy W Behrens
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6. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.

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7. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

Authors: Subra Kugathasan; Robert N Baldassano; Jonathan P Bradfield; Patrick M A Sleiman; Marcin Imielinski; Stephen L Guthery; Salvatore Cucchiara; Cecilia E Kim; Edward C Frackelton; Kiran Annaiah; Joseph T Glessner; Erin Santa; Tara Willson; Andrew W Eckert; Erin Bonkowski; Julie L Shaner; Ryan M Smith; F George Otieno; Nicholas Peterson; Debra J Abrams; Rosetta M Chiavacci; Robert Grundmeier; Petar Mamula; Gitit Tomer; David A Piccoli; Dimitri S Monos; Vito Annese; Lee A Denson; Struan F A Grant; Hakon Hakonarson
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8. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Authors: Christopher E Lowe; Jason D Cooper; Todd Brusko; Neil M Walker; Deborah J Smyth; Rebecca Bailey; Kirsi Bourget; Vincent Plagnol; Sarah Field; Mark Atkinson; David G Clayton; Linda S Wicker; John A Todd
Journal: Nat Genet Date: 2007-08-05 Impact factor: 38.330

9. Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Authors: Li Wen; Ruth E Ley; Pavel Yu Volchkov; Peter B Stranges; Lia Avanesyan; Austin C Stonebraker; Changyun Hu; F Susan Wong; Gregory L Szot; Jeffrey A Bluestone; Jeffrey I Gordon; Alexander V Chervonsky
Journal: Nature Date: 2008-09-21 Impact factor: 49.962

10. WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013.

Authors: Jing Wang; Dexter Duncan; Zhiao Shi; Bing Zhang
Journal: Nucleic Acids Res Date: 2013-05-23 Impact factor: 16.971

203 in total

1. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Authors: Eli A Stahl; Soumya Raychaudhuri; Elaine F Remmers; Gang Xie; Stephen Eyre; Brian P Thomson; Yonghong Li; Fina A S Kurreeman; Alexandra Zhernakova; Anne Hinks; Candace Guiducci; Robert Chen; Lars Alfredsson; Christopher I Amos; Kristin G Ardlie; Anne Barton; John Bowes; Elisabeth Brouwer; Noel P Burtt; Joseph J Catanese; Jonathan Coblyn; Marieke J H Coenen; Karen H Costenbader; Lindsey A Criswell; J Bart A Crusius; Jing Cui; Paul I W de Bakker; Philip L De Jager; Bo Ding; Paul Emery; Edward Flynn; Pille Harrison; Lynne J Hocking; Tom W J Huizinga; Daniel L Kastner; Xiayi Ke; Annette T Lee; Xiangdong Liu; Paul Martin; Ann W Morgan; Leonid Padyukov; Marcel D Posthumus; Timothy R D J Radstake; David M Reid; Mark Seielstad; Michael F Seldin; Nancy A Shadick; Sophia Steer; Paul P Tak; Wendy Thomson; Annette H M van der Helm-van Mil; Irene E van der Horst-Bruinsma; C Ellen van der Schoot; Piet L C M van Riel; Michael E Weinblatt; Anthony G Wilson; Gert Jan Wolbink; B Paul Wordsworth; Cisca Wijmenga; Elizabeth W Karlson; Rene E M Toes; Niek de Vries; Ann B Begovich; Jane Worthington; Katherine A Siminovitch; Peter K Gregersen; Lars Klareskog; Robert M Plenge
Journal: Nat Genet Date: 2010-05-09 Impact factor: 38.330

Review 2. The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases.

Authors: Helena Tlaskalová-Hogenová; Renata Stěpánková; Hana Kozáková; Tomáš Hudcovic; Luca Vannucci; Ludmila Tučková; Pavel Rossmann; Tomáš Hrnčíř; Miloslav Kverka; Zuzana Zákostelská; Klára Klimešová; Jaroslava Přibylová; Jiřina Bártová; Daniel Sanchez; Petra Fundová; Dana Borovská; Dagmar Srůtková; Zdeněk Zídek; Martin Schwarzer; Pavel Drastich; David P Funda
Journal: Cell Mol Immunol Date: 2011-01-31 Impact factor: 11.530

3. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.

Authors: Lara Bossini-Castillo; Jose-Ezequiel Martin; Jasper Broen; Olga Gorlova; Carmen P Simeón; Lorenzo Beretta; Madelon C Vonk; Jose Luis Callejas; Ivan Castellví; Patricia Carreira; Francisco José García-Hernández; Mónica Fernández Castro; Marieke J H Coenen; Gabriela Riemekasten; Torsten Witte; Nicolas Hunzelmann; Alexander Kreuter; Jörg H W Distler; Bobby P Koeleman; Alexandre E Voskuyl; Annemie J Schuerwegh; Øyvind Palm; Roger Hesselstrand; Annika Nordin; Paolo Airó; Claudio Lunardi; Raffaella Scorza; Paul Shiels; Jacob M van Laar; Ariane Herrick; Jane Worthington; Christopher Denton; Filemon K Tan; Frank C Arnett; Sandeep K Agarwal; Shervin Assassi; Carmen Fonseca; Maureen D Mayes; Timothy R D J Radstake; Javier Martin
Journal: Hum Mol Genet Date: 2011-11-10 Impact factor: 6.150

4. Fine points in mapping autoimmunity.

Authors: Constantin Polychronakos
Journal: Nat Genet Date: 2011-11-28 Impact factor: 38.330

Review 5. Multiple sclerosis.

Authors: Alyssa Nylander; David A Hafler
Journal: J Clin Invest Date: 2012-04-02 Impact factor: 14.808

Review 10. Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.

Authors: Altin Gjymishka; Roxana M Coman; Todd M Brusko; Sarah C Glover
Journal: Immunotherapy Date: 2013-12 Impact factor: 4.196