| Literature DB >> 15838509 |
Yuta Kochi1, Ryo Yamada, Akari Suzuki, John B Harley, Senji Shirasawa, Tetsuji Sawada, Sang-Cheol Bae, Shinya Tokuhiro, Xiaotian Chang, Akihiro Sekine, Atsushi Takahashi, Tatsuhiko Tsunoda, Yozo Ohnishi, Kenneth M Kaufman, Changsoo Paul Kang, Changwon Kang, Shigeru Otsubo, Wako Yumura, Akio Mimori, Takao Koike, Yusuke Nakamura, Takehiko Sasazuki, Kazuhiko Yamamoto.
Abstract
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.Entities:
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Year: 2005 PMID： 15838509 PMCID： PMC1362949 DOI： 10.1038/ng1540
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330