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Literature DB >> 20453842

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Eli A Stahl¹, Soumya Raychaudhuri, Elaine F Remmers, Gang Xie, Stephen Eyre, Brian P Thomson, Yonghong Li, Fina A S Kurreeman, Alexandra Zhernakova, Anne Hinks, Candace Guiducci, Robert Chen, Lars Alfredsson, Christopher I Amos, Kristin G Ardlie, Anne Barton, John Bowes, Elisabeth Brouwer, Noel P Burtt, Joseph J Catanese, Jonathan Coblyn, Marieke J H Coenen, Karen H Costenbader, Lindsey A Criswell, J Bart A Crusius, Jing Cui, Paul I W de Bakker, Philip L De Jager, Bo Ding, Paul Emery, Edward Flynn, Pille Harrison, Lynne J Hocking, Tom W J Huizinga, Daniel L Kastner, Xiayi Ke, Annette T Lee, Xiangdong Liu, Paul Martin, Ann W Morgan, Leonid Padyukov, Marcel D Posthumus, Timothy R D J Radstake, David M Reid, Mark Seielstad, Michael F Seldin, Nancy A Shadick, Sophia Steer, Paul P Tak, Wendy Thomson, Annette H M van der Helm-van Mil, Irene E van der Horst-Bruinsma, C Ellen van der Schoot, Piet L C M van Riel, Michael E Weinblatt, Anthony G Wilson, Gert Jan Wolbink, B Paul Wordsworth, Cisca Wijmenga, Elizabeth W Karlson, Rene E M Toes, Niek de Vries, Ann B Begovich, Jane Worthington, Katherine A Siminovitch, Peter K Gregersen, Lars Klareskog, Robert M Plenge.

Abstract

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Autoantibodies

Year: 2010 PMID： 20453842 PMCID： PMC4243840 DOI： 10.1038/ng.582

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

56 in total

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Journal: Nat Genet Date: 2009-10-18 Impact factor: 38.330

Review 2. Structural alterations in peptide-MHC recognition by self-reactive T cell receptors.

Authors: Kai W Wucherpfennig; Melissa J Call; Lu Deng; Roy Mariuzza
Journal: Curr Opin Immunol Date: 2009-08-19 Impact factor: 7.486

3. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Authors: Calliope A Dendrou; Vincent Plagnol; Erik Fung; Jennie H M Yang; Kate Downes; Jason D Cooper; Sarah Nutland; Gillian Coleman; Matthew Himsworth; Matthew Hardy; Oliver Burren; Barry Healy; Neil M Walker; Kerstin Koch; Willem H Ouwehand; John R Bradley; Nicholas J Wareham; John A Todd; Linda S Wicker
Journal: Nat Genet Date: 2009-08-23 Impact factor: 38.330

4. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

Authors: Robert M Plenge; Mark Seielstad; Leonid Padyukov; Annette T Lee; Elaine F Remmers; Bo Ding; Anthony Liew; Houman Khalili; Alamelu Chandrasekaran; Leela R L Davies; Wentian Li; Adrian K S Tan; Carine Bonnard; Rick T H Ong; Anbupalam Thalamuthu; Sven Pettersson; Chunyu Liu; Chao Tian; Wei V Chen; John P Carulli; Evan M Beckman; David Altshuler; Lars Alfredsson; Lindsey A Criswell; Christopher I Amos; Michael F Seldin; Daniel L Kastner; Lars Klareskog; Peter K Gregersen
Journal: N Engl J Med Date: 2007-09-05 Impact factor: 91.245

5. Common and different genetic background for rheumatoid arthritis and coeliac disease.

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Journal: Hum Mol Genet Date: 2009-07-31 Impact factor: 6.150

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Authors: Robert M Plenge
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7. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

Authors: Philip L De Jager; Xiaoming Jia; Joanne Wang; Paul I W de Bakker; Linda Ottoboni; Neelum T Aggarwal; Laura Piccio; Soumya Raychaudhuri; Dong Tran; Cristin Aubin; Rebeccah Briskin; Susan Romano; Sergio E Baranzini; Jacob L McCauley; Margaret A Pericak-Vance; Jonathan L Haines; Rachel A Gibson; Yvonne Naeglin; Bernard Uitdehaag; Paul M Matthews; Ludwig Kappos; Chris Polman; Wendy L McArdle; David P Strachan; Denis Evans; Anne H Cross; Mark J Daly; Alastair Compston; Stephen J Sawcer; Howard L Weiner; Stephen L Hauser; David A Hafler; Jorge R Oksenberg
Journal: Nat Genet Date: 2009-06-14 Impact factor: 38.330

8. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Authors: Soumya Raychaudhuri; Robert M Plenge; Elizabeth J Rossin; Aylwin C Y Ng; Shaun M Purcell; Pamela Sklar; Edward M Scolnick; Ramnik J Xavier; David Altshuler; Mark J Daly
Journal: PLoS Genet Date: 2009-06-26 Impact factor: 5.917

9. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

Authors: Peter K Gregersen; Chistopher I Amos; Annette T Lee; Yue Lu; Elaine F Remmers; Daniel L Kastner; Michael F Seldin; Lindsey A Criswell; Robert M Plenge; V Michael Holers; Ted R Mikuls; Tuulikki Sokka; Larry W Moreland; S Louis Bridges; Gang Xie; Ann B Begovich; Katherine A Siminovitch
Journal: Nat Genet Date: 2009-06-07 Impact factor: 38.330

10. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Authors: Soumya Raychaudhuri; Brian P Thomson; Elaine F Remmers; Stephen Eyre; Anne Hinks; Candace Guiducci; Joseph J Catanese; Gang Xie; Eli A Stahl; Robert Chen; Lars Alfredsson; Christopher I Amos; Kristin G Ardlie; Anne Barton; John Bowes; Noel P Burtt; Monica Chang; Jonathan Coblyn; Karen H Costenbader; Lindsey A Criswell; J Bart A Crusius; Jing Cui; Phillip L De Jager; Bo Ding; Paul Emery; Edward Flynn; Pille Harrison; Lynne J Hocking; Tom W J Huizinga; Daniel L Kastner; Xiayi Ke; Fina A S Kurreeman; Annette T Lee; Xiangdong Liu; Yonghong Li; Paul Martin; Ann W Morgan; Leonid Padyukov; David M Reid; Mark Seielstad; Michael F Seldin; Nancy A Shadick; Sophia Steer; Paul P Tak; Wendy Thomson; Annette H M van der Helm-van Mil; Irene E van der Horst-Bruinsma; Michael E Weinblatt; Anthony G Wilson; Gert Jan Wolbink; Paul Wordsworth; David Altshuler; Elizabeth W Karlson; Rene E M Toes; Niek de Vries; Ann B Begovich; Katherine A Siminovitch; Jane Worthington; Lars Klareskog; Peter K Gregersen; Mark J Daly; Robert M Plenge
Journal: Nat Genet Date: 2009-11-08 Impact factor: 38.330

596 in total

1. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.

Authors: Yuta Kochi; Yukinori Okada; Akari Suzuki; Katsunori Ikari; Chikashi Terao; Atsushi Takahashi; Keiko Yamazaki; Naoya Hosono; Keiko Myouzen; Tatsuhiko Tsunoda; Naoyuki Kamatani; Tatsuya Furuichi; Shiro Ikegawa; Koichiro Ohmura; Tsuneyo Mimori; Fumihiko Matsuda; Takuji Iwamoto; Shigeki Momohara; Hisashi Yamanaka; Ryo Yamada; Michiaki Kubo; Yusuke Nakamura; Kazuhiko Yamamoto
Journal: Nat Genet Date: 2010-05-09 Impact factor: 38.330

Review 2. The epigenetics of autoimmunity.

Authors: Francesca Meda; Marco Folci; Andrea Baccarelli; Carlo Selmi
Journal: Cell Mol Immunol Date: 2011-01-31 Impact factor: 11.530

3. Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.

Authors: T T Glant; V A Adarichev; F Boldizsar; T Besenyei; A Laszlo; K Mikecz; T A Rauch
Journal: Genes Immun Date: 2012-03-08 Impact factor: 2.676

Review 4. RA in 2011: Advances in diagnosis, treatment and definition of remission.

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5. A CCR6 variant strongly associated with rheumatoid arthritis in two populations is not associated with ankylosing spondylitis.

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7. Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.

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Journal: Arthritis Rheum Date: 2012-10