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Literature DB >> 22005987

Understanding type 1 diabetes through genetics: advances and prospects.

Abstract

Starting with early crucial discoveries of the role of the major histocompatibility complex, genetic studies have long had a role in understanding the biology of type 1 diabetes (T1D), which is one of the most heritable common diseases. Recent genome-wide association studies (GWASs) have given us a clearer picture of the allelic architecture of genetic susceptibility to T1D. Fine mapping and functional studies are gradually revealing the complex mechanisms whereby immune self-tolerance is lost, involving multiple aspects of adaptive immunity. The triggering of these events by dysregulation of the innate immune system has also been implicated by genetic evidence. Finally, genetic prediction of T1D risk is showing promise of use for preventive strategies.

Entities: Disease

Mesh：

Year: 2011 PMID： 22005987 DOI： 10.1038/nrg3069

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

95 in total

Review 1. Use of nonobese diabetic mice to understand human type 1 diabetes.

Authors: Terri C Thayer; S Brian Wilson; Clayton E Mathews
Journal: Endocrinol Metab Clin North Am Date: 2010-07-08 Impact factor: 4.741

2. Increased incidence and prevalence of diabetes mellitus in Down's syndrome.

Authors: J C Van Goor; G G Massa; R Hirasing
Journal: Arch Dis Child Date: 1997-08 Impact factor: 3.791

Review 3. What can exome sequencing do for you?

Authors: Jacek Majewski; Jeremy Schwartzentruber; Emilie Lalonde; Alexandre Montpetit; Nada Jabado
Journal: J Med Genet Date: 2011-07-05 Impact factor: 6.318

4. Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients.

Authors: Dimitry A Chistiakov; Natalia V Voronova; Kirill V Savost'Anov; Rustam I Turakulov
Journal: Hum Immunol Date: 2010-08-22 Impact factor: 2.850

5. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.

Authors: Sally C Kent; Yahua Chen; Lisa Bregoli; Sue M Clemmings; Norma Sue Kenyon; Camillo Ricordi; Bernhard J Hering; David A Hafler
Journal: Nature Date: 2005-05-12 Impact factor: 49.962

6. Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3' +6230G>A polymorphism.

Authors: S M Anjos; W Shao; L Marchand; C Polychronakos
Journal: Genes Immun Date: 2005-06 Impact factor: 2.676

7. Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line.

Authors: D K Wherrett; S M Singer; H O McDevitt
Journal: Diabetes Date: 1997-12 Impact factor: 9.461

8. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.

Authors: Hakon Hakonarson; Hui-Qi Qu; Jonathan P Bradfield; Luc Marchand; Cecilia E Kim; Joseph T Glessner; Rosemarie Grabs; Tracy Casalunovo; Shayne P Taback; Edward C Frackelton; Andrew W Eckert; Kiran Annaiah; Margaret L Lawson; F George Otieno; Erin Santa; Julie L Shaner; Ryan M Smith; Chioma C Onyiah; Robert Skraban; Rosetta M Chiavacci; Luke J Robinson; Charles A Stanley; Susan E Kirsch; Marcella Devoto; Dimitri S Monos; Struan F A Grant; Constantin Polychronakos
Journal: Diabetes Date: 2008-01-15 Impact factor: 9.461

9. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Authors: Christopher E Lowe; Jason D Cooper; Todd Brusko; Neil M Walker; Deborah J Smyth; Rebecca Bailey; Kirsi Bourget; Vincent Plagnol; Sarah Field; Mark Atkinson; David G Clayton; Linda S Wicker; John A Todd
Journal: Nat Genet Date: 2007-08-05 Impact factor: 38.330

10. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.

Authors: Patrick Concannon; Wei-Min Chen; Cécile Julier; Grant Morahan; Beena Akolkar; Henry A Erlich; Joan E Hilner; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Journal: Diabetes Date: 2009-01-09 Impact factor: 9.461

97 in total

Review 1. Five years of GWAS discovery.

Authors: Peter M Visscher; Matthew A Brown; Mark I McCarthy; Jian Yang
Journal: Am J Hum Genet Date: 2012-01-13 Impact factor: 11.025

2. Familial risks in understanding type 1 diabetes genetics.

Authors: Kari Hemminki
Journal: Nat Rev Genet Date: 2012-01-17 Impact factor: 53.242

3. Autoimmunity's next top models.

Authors: Hartmut Wekerle; Alexander Flügel; Lars Fugger; Georg Schett; David Serreze
Journal: Nat Med Date: 2012-01-06 Impact factor: 53.440

Review 4. MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research.

Authors: Jonàs Juan-Mateu; Olatz Villate; Décio L Eizirik
Journal: Eur J Endocrinol Date: 2015-12-01 Impact factor: 6.664

5. Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes.

Authors: Özkan Aydemir; Janelle A Noble; Jeffrey A Bailey; Åke Lernmark; Patrick Marsh; Agnes Andersson Svärd; Frank Bearoff; Elizabeth P Blankenhorn; John P Mordes
Journal: Diabetes Date: 2019-04-08 Impact factor: 9.461

Review 6. Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes.

Authors: Joachim Storling; Caroline Anna Brorsson
Journal: Curr Diab Rep Date: 2013-10 Impact factor: 4.810

Review 7. Novel biomarkers in type 1 diabetes.

Authors: Yulan Jin; Jin-Xiong She
Journal: Rev Diabet Stud Date: 2012-12-28