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Literature DB >> 19010685

Engineered production of iso-migrastatin in heterologous Streptomyces hosts.

Zhiyang Feng¹, Liyan Wang, Scott R Rajski, Zhinan Xu, Marie F Coeffet-LeGal, Ben Shen.

Abstract

Glutarimide-containing polyketides such as migrastatin (MGS) are well known for their ability to inhibit tumor cell migration. We have previously shown that MGS is derived from iso-migrastatin (iso-MGS) via a H(2)O-mediated ring-expansion rearrangement. A bacterial artificial chromosome (BAC) library of Streptomyces platensis NRRL18993, an iso-MGS producer, was constructed. From this library, pBS11001, a BAC clone harboring the intact iso-MGS biosynthetic gene cluster, was identified. Mobilization of pBS11001 into five heterologous Streptomyces hosts afforded recombinant strains, SB11001, SB11002, SB11003, SB11004, and SB11005, respectively. Under a standard set of media and fermentation conditions, the recombinant strains all produced the same profile of iso-MGS as that of S. platensis NRRL18993. These findings highlight the strength and flexibility of the BAC-based technology for natural product production and engineering in heterologous Streptomyces model hosts.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2008 PMID： 19010685 PMCID： PMC3075207 DOI： 10.1016/j.bmc.2008.10.074

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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