Literature DB >> 11132958

Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.

K Nakae1, Y Yoshimoto, T Sawa, Y Homma, M Hamada, T Takeuchi, M Imoto.   

Abstract

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

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Year:  2000        PMID： 11132958     DOI： 10.7164/antibiotics.53.1130

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  33 in total

1.  Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones.

Authors:  Anniefer N Magpusao; Richard T Desmond; Katelyn J Billings; Gabriel Fenteany; Mark W Peczuh
Journal:  Bioorg Med Chem Lett       Date:  2010-07-25       Impact factor: 2.823

2.  Velocity fields in a collectively migrating epithelium.

Authors:  L Petitjean; M Reffay; E Grasland-Mongrain; M Poujade; B Ladoux; A Buguin; P Silberzan
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

3.  Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues.

Authors:  Jianhua Ju; Si-Kyu Lim; Hui Jiang; Jeong-Woo Seo; Yeng Her; Ben Shen
Journal:  Org Lett       Date:  2006-12-07       Impact factor: 6.005

4.  Garbled messages and corrupted translations.

Authors:  Tilman Schneider-Poetsch; Takeo Usui; Daisuke Kaida; Minoru Yoshida
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

5.  Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.

Authors:  Pavel Nagorny; Isaac Krauss; Jón T Njardarson; Lucy Perez; Christoph Gaul; Guangli Yang; Ouathek Ouerfelli; Samuel J Danishefsky
Journal:  Tetrahedron Lett       Date:  2010-07-28       Impact factor: 2.415

6.  Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.

Authors:  Dandan Shan; Lin Chen; Jon T Njardarson; Christoph Gaul; Xiaojing Ma; Samuel J Danishefsky; Xin-Yun Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-22       Impact factor: 11.205

7.  Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

Authors:  Zhiming Wang; Sabrina Castellano; Sape S Kinderman; Christian E Argueta; Anwar B Beshir; Gabriel Fenteany; Ohyun Kwon
Journal:  Chemistry       Date:  2010-11-09       Impact factor: 5.236

8.  Fusarisetin A: Scalable Total Synthesis and Related Studies.

Authors:  Jing Xu; Eduardo J E Caro-Diaz; Michelle H Lacoske; Chao-I Hung; Colin Jamora; Emmanuel A Theodorakis
Journal:  Chem Sci       Date:  2012-08-23       Impact factor: 9.825

9.  Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

Authors:  Tilman Schneider-Poetsch; Jianhua Ju; Daniel E Eyler; Yongjun Dang; Shridhar Bhat; William C Merrick; Rachel Green; Ben Shen; Jun O Liu
Journal:  Nat Chem Biol       Date:  2010-01-31       Impact factor: 15.040

10.  Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum.

Authors:  Jixun Zhan; Anna M Burns; Manping X Liu; Stanley H Faeth; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2007-02-08       Impact factor: 4.050
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