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Literature DB >> 18528836

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum.

Steven A Rogers¹, Christian Melander.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18528836 DOI： 10.1002/anie.200800862

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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29 in total

1. Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems.

Authors: Sean D Stowe; Ashley T Tucker; Richele Thompson; Amanda Piper; Justin J Richards; Steven A Rogers; Laura D Mathies; Christian Melander; John Cavanagh
Journal: Drug Chem Toxicol Date: 2012-01-31 Impact factor: 3.356

Review 2. Small molecule control of bacterial biofilms.

Authors: Roberta J Worthington; Justin J Richards; Christian Melander
Journal: Org Biomol Chem Date: 2012-10-07 Impact factor: 3.876

3. 2-Aminopyrimidine as a novel scaffold for biofilm modulation.

Authors: Erick A Lindsey; Roberta J Worthington; Cristina Alcaraz; Christian Melander
Journal: Org Biomol Chem Date: 2012-02-02 Impact factor: 3.876

4. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds.

Authors: Morgan E Milton; C Leigh Allen; Erik A Feldmann; Benjamin G Bobay; David K Jung; Matthew D Stephens; Roberta J Melander; Kelly E Theisen; Daina Zeng; Richele J Thompson; Christian Melander; John Cavanagh
Journal: Mol Microbiol Date: 2017-08-16 Impact factor: 3.501

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum.

1. Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems.

Review 2. Small molecule control of bacterial biofilms.

3. 2-Aminopyrimidine as a novel scaffold for biofilm modulation.

4. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds.

5. Marine sponge alkaloids as a source of anti-bacterial adjuvants.

6. Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents.

7. 5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus.

8. Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

9. Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

10. Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.