Literature DB >> 26877862

Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Matthew D Stephens1, Veroncia B Hubble1, Robert K Ernst2, Monique L van Hoek3, Roberta J Melander1, John Cavanagh4, Christian Melander1.   

Abstract

A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containg an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.

Entities:  

Year:  2015        PMID： 26877862      PMCID： PMC4749165          DOI： 10.1039/C5MD00353A

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  22 in total

1.  Tularemia and once-daily gentamicin.

Authors:  Ali Hassoun; Richard Spera; John Dunkel
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Francisella philomiragia biofilm formation and interaction with the aquatic protist Acanthamoeba castellanii.

Authors:  Anne B Verhoeven; Meghan W Durham-Colleran; Tony Pierson; William T Boswell; Monique L Van Hoek
Journal:  Biol Bull       Date:  2010-10       Impact factor: 1.818

3.  Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum.

Authors:  Steven A Rogers; Christian Melander
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

4.  Contamination of natural waters and mud with Pasteurella tularensis and tularemia in beavers and muskrats in the northwestern United States.

Authors:  R R PARKER; E A STEINHAUS; G M KOHLS; W L JELLISON
Journal:  Bull Natl Inst Health       Date:  1951

5.  Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance.

Authors:  Tyler L Harris; Roberta J Worthington; Lauren E Hittle; Daniel V Zurawski; Robert K Ernst; Christian Melander
Journal:  ACS Chem Biol       Date:  2013-10-28       Impact factor: 5.100

6.  A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity.

Authors:  Zhaoming Su; Steven A Rogers; W Steve McCall; Alicia C Smith; Sindhu Ravishankar; Trey Mullikin; Christian Melander
Journal:  Org Biomol Chem       Date:  2010-04-29       Impact factor: 3.876

7.  Azithromycin effectiveness against intracellular infections of Francisella.

Authors:  Saira Ahmad; Lyman Hunter; Aiping Qin; Barbara J Mann; Monique L van Hoek
Journal:  BMC Microbiol       Date:  2010-04-23       Impact factor: 3.605

8.  Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

Authors:  Tyler L Harris; Roberta J Worthington; Christian Melander
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-09       Impact factor: 15.336

Review 9.  Streptomycin and alternative agents for the treatment of tularemia: review of the literature.

Authors:  G Enderlin; L Morales; R F Jacobs; J T Cross
Journal:  Clin Infect Dis       Date:  1994-07       Impact factor: 9.079

10.  The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

Authors:  Robert W Huigens; Samuel Reyes; Catherine S Reed; Cynthia Bunders; Steven A Rogers; Andrew T Steinhauer; Christian Melander
Journal:  Bioorg Med Chem       Date:  2009-12-06       Impact factor: 3.641
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  8 in total

1.  Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin.

Authors:  Bradley M Minrovic; Veronica B Hubble; William T Barker; Leigh A Jania; Roberta J Melander; Beverly H Koller; Christian Melander
Journal:  ACS Med Chem Lett       Date:  2019-04-17       Impact factor: 4.345

2.  New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii.

Authors:  Bradley M Minrovic; David Jung; Roberta J Melander; Christian Melander
Journal:  ACS Infect Dis       Date:  2018-06-25       Impact factor: 5.084

3.  2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Authors:  Albert B Jeon; Andrés Obregón-Henao; David F Ackart; Brendan K Podell; Juan M Belardinelli; Mary Jackson; Tuan V Nguyen; Meghan S Blackledge; Roberta J Melander; Christian Melander; Benjamin K Johnson; Robert B Abramovitch; Randall J Basaraba
Journal:  PLoS One       Date:  2017-07-27       Impact factor: 3.240

4.  Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery.

Authors:  Jan Honegr; Rafael Dolezal; David Malinak; Marketa Benkova; Ondrej Soukup; Joyce S F D de Almeida; Tanos C C Franca; Kamil Kuca; Roman Prymula
Journal:  Molecules       Date:  2018-01-04       Impact factor: 4.411

Review 5.  Two-Component Systems in Francisella Species.

Authors:  Monique L van Hoek; Ky V Hoang; John S Gunn
Journal:  Front Cell Infect Microbiol       Date:  2019-06-12       Impact factor: 5.293

Review 6.  Genetic Determinants of Antibiotic Resistance in Francisella.

Authors:  Stephen J Kassinger; Monique L van Hoek
Journal:  Front Microbiol       Date:  2021-05-12       Impact factor: 5.640

7.  Francisella philomiragia Infection and Lethality in Mammalian Tissue Culture Cell Models, Galleria mellonella, and BALB/c Mice.

Authors:  Crystal N Propst; Stephanie L Pylypko; Ryan J Blower; Saira Ahmad; Mohammad Mansoor; Monique L van Hoek
Journal:  Front Microbiol       Date:  2016-05-24       Impact factor: 5.640

8.  Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens.

Authors:  Yuan Liu; Yuqian Jia; Kangni Yang; Ziwen Tong; Jingru Shi; Ruichao Li; Xia Xiao; Wenkai Ren; Rüdiger Hardeland; Russel J Reiter; Zhiqiang Wang
Journal:  Theranostics       Date:  2020-08-29       Impact factor: 11.556
  8 in total

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