Literature DB >> 27876320

Marine sponge alkaloids as a source of anti-bacterial adjuvants.

Roberta J Melander1, Hong-Bing Liu2, Matthew D Stephens1, Carole A Bewley2, Christian Melander3.   

Abstract

Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance. Copyright Â
© 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Adjuvant; Antibiotic; Biofilm; Marine sponge; Pyrrole-imidazole alkaloid

Mesh：

Substances：

Year:  2016        PMID： 27876320      PMCID： PMC5776710          DOI： 10.1016/j.bmcl.2016.11.018

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  41 in total

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Review 6.  Marine natural products.

Authors:  John W Blunt; Brent R Copp; Robert A Keyzers; Murray H G Munro; Michèle R Prinsep
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Review 7.  Marine sponges: potential sources of new antimicrobial drugs.

Authors:  M S Laport; O C S Santos; G Muricy
Journal:  Curr Pharm Biotechnol       Date:  2009-01       Impact factor: 2.837

8.  Syntheses of Sceptrins and Nakamuric Acid and Insights into the Biosyntheses of Pyrrole-Imidazole Dimers.

Authors:  Xiaolei Wang; Yang Gao; Zhiqiang Ma; Rodrigo A Rodriguez; Zhi-Xiang Yu; Chuo Chen
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9.  Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

Authors:  Justin J Richards; Samuel Reyes; Sean D Stowe; Ashley T Tucker; T Eric Ballard; Laura D Mathies; John Cavanagh; Christian Melander
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

10.  Motualevic acids A-F, antimicrobial acids from the sponge Siliquariaspongia sp.

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  8 in total

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3.  Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria.

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Journal:  Mar Drugs       Date:  2020-06-23       Impact factor: 5.118

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Review 6.  Secondary metabolites from marine sponges of the genus Agelas: a comprehensive update insight on structural diversity and bioactivity.

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Journal:  RSC Adv       Date:  2022-03-09       Impact factor: 3.361

7.  Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island.

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8.  Synthesis and Antibacterial Analysis of Analogues of the Marine Alkaloid Pseudoceratidine.

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  8 in total

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