Literature DB >> 28537316

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus.

Grant A Edwards1, Nataliia V Shymanska, Joshua G Pierce.   

Abstract

Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC50 values as low as 0.78 μM, and disperse pre-formed biofilms with IC50 values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes.

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Year:  2017        PMID： 28537316      PMCID： PMC5526077          DOI： 10.1039/c7cc03626d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  25 in total

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Review 5.  Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules.

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6.  Synoxazolidinones A and B: novel bioactive alkaloids from the ascidian Synoicum pulmonaria.

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7.  Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus.

Authors:  K Sieradzki; A Tomasz
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

8.  Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles.

Authors:  Nataliia V Shymanska; Il Hwan An; Sebastián Guevara-Zuluaga; Joshua G Pierce
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Review 9.  P. aeruginosa quorum-sensing systems and virulence.

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Journal:  Curr Opin Microbiol       Date:  2003-02       Impact factor: 7.934

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4.  5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms.

Authors:  Bram H Frohock; Jessica M Gilbertie; Jennifer C Daiker; Lauren V Schnabel; Joshua G Pierce
Journal:  Chembiochem       Date:  2019-12-30       Impact factor: 3.164

5.  Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog.

Authors:  K F Griewisch; J G Pierce; J R Elfenbein
Journal:  Appl Environ Microbiol       Date:  2020-10-01       Impact factor: 4.792

6.  Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence.

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Review 7.  Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition.

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Journal:  Front Cell Infect Microbiol       Date:  2019-04-02       Impact factor: 5.293

Review 8.  Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms.

Authors:  Audrey R N Ndukwe; Sandra Wiedbrauk; Nathan R B Boase; Kathryn E Fairfull-Smith
Journal:  Chem Asian J       Date:  2022-04-13
  8 in total

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