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Literature DB >> 23047322

Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

Tyler L Harris¹, Roberta J Worthington, Christian Melander.

Abstract

Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi-drug-resistant bacteria, such as MRSA, to clinically available antibiotics are a promising alternative to the development of novel antimicrobials. Pictured is a potent small molecule (1) that, at sub-minimum inhibitory concentration (sub-MIC) levels, lowers the MIC of oxacillin (2) against a number of MRSA strains by up to 512-fold.

Entities: CellLine Chemical Disease Species

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Year: 2012 PMID： 23047322 PMCID： PMC3829614 DOI： 10.1002/anie.201206911

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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